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TL;DR
This preclinical study investigated a novel method to engineer perfused blood vessel structures for potential tissue engineering applications.
Plastic and Reconstructive Surgery Global Open · 9 authors, 1 centre
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This preclinical study investigated a novel method to engineer perfused blood vessel structures for potential tissue engineering applications.
This preclinical study investigated a novel method to engineer perfused blood vessel structures for potential tissue engineering applications. These loops were embedded in a collagen matrix, where subsequent dissolution of the PVA created hollow channels. The channels were seeded with human aortic smooth muscle cells and endothelial cells and subjected to a 5-day perfusion protocol using a peristaltic pump. Key results showed that PVA could be sterilized with ethanol without degrading and demonstrated good biocompatibility. After perfusion, endothelial cells aligned with the direction of flow, a physiologic response.