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TL;DR
Over 12 months, this regimen was associated with a marked reduction in emergency room visits and reported subjective improvement in functioning.
Therapeutic Advances in Rare Disease
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Over 12 months, this regimen was associated with a marked reduction in emergency room visits and reported subjective improvement in functioning.
This case report describes a 26-year-old woman with MELAS syndrome who had 77 emergency room visits for suspected metabolic stroke between ages 13 and 24, despite treatment with high-dose oral L-arginine and L-citrulline. The patient had only one emergency room visit during this period, a substantial reduction from her prior frequency. Caregivers reported subjective improvements in her overall level of functioning and cognition. The treatment was well-tolerated, though it required additional bicarbonate supplementation.