**Background:** Chronic diseases are the leading cause of death globally, and in the Netherlands, 59% of the population had one or more chronic diseases in 2020. Single disease management programs (DMPs) for COPD, cardiovascular disease, and diabetes mellitus type 2 are widely implemented in Dutch primary care but have failed to improve patients' health-related quality of life. These programs focus on medical aspects of specific conditions with less attention to multimorbidity or social determinants. Person-centred integrated care (PC-IC) has been proposed as an alternative, aiming to ensure patients' values and concerns shape how long-term conditions are managed. This study describes the development of a PC-IC approach for patients with one or more chronic diseases in Dutch primary care, co-designed with academics, healthcare professionals, patients, and healthcare insurers.
**Methods:** The multiphase development process ran from March 2019 to July 2020, conducted with three large primary care cooperatives in the eastern Netherlands (Nijmegen region: 168 GPs, ~290,000 inhabitants; Arnhem region: 193 GPs, ~440,000 inhabitants; Doetinchem region: 116 GPs, ~150,000 inhabitants). Phase 1 involved a scoping review (searching PubMed, EMBASE, Cochrane, TRIP, and GIN databases up to August 27, 2019) and document analysis of Dutch chronic disease care standards and GP guidelines for COPD, CVD, and DM2. Phase 2 used online qualitative surveys with 52 healthcare professionals (93% response rate from 56 invited), including 16 GPs, 15 practice nurses, and various allied health professionals. Phase 3 involved semi-structured telephone interviews with 9 patients (8 male, mean age 65 years, range 58-79) with DM2, COPD, and/or CVD. Phase 4 gathered feedback from health insurers and the Dutch Centre of Expertise on Health Disparities (Pharos). Data were analyzed using inductive thematic coding with ATLAS.ti version 8.4.15.
**Key Results:** The scoping review identified 18 eligible publications (published 2007-2019, 67% from 2015-2019). Key elements identified included: assessment of multiple domains (medical, functional, mental health, social functioning), case management, clinical assessment including disease burden and treatment burden, eliciting patient preferences and priorities, and collaborative care planning. The document analysis produced a list of unique interventions across categories including physiological functioning, physical functioning, quality of life, and social functioning. Healthcare professionals generally agreed with the PC-IC vision, anticipating improved patient motivation and long-term time savings, but raised concerns about time intensity, suitability for patients with limited health skills, and potential medicalisation of non-medical problems. Patients valued personalized care, longer consultation times, and the partnership approach, but highlighted accessibility concerns for those with low literacy or computer skills. Health insurers requested clearer inclusion criteria and attention to workforce shortages. Pharos experts noted the digital questionnaire (Nijmegen Clinical Screening Instrument) needed language and layout improvements for people with limited health literacy.
**Clinical Implications:** The developed PC-IC approach represents a shift from disease-focused protocols to holistic, patient-centred care for chronic disease management in Dutch primary care. The approach includes cyclical assessment of integral health status across multiple domains, collaborative goal setting, shared decision-making on interventions, and documented individual care plans with case management by practice nurses. While stakeholders anticipated benefits including improved patient motivation, better insight into health status, and more efficient care delivery, the authors acknowledge that the anticipated superiority over current DMPs has yet to be demonstrated. A cluster randomised trial is underway to assess effects on health-related quality of life, self-management behaviour, and patient experience. The study predominantly focused on micro-level service delivery; meso and macro level components (financing, governance, workforce) require further study. A complementary payment model has been published separately.