**Background:** Cardiovascular disease (CVD) risk begins in childhood, and metabolic syndrome (MetS) prevalence is rising in young adults, particularly women. University students often exhibit unhealthy weight gain, low physical activity (PA), poor diet, and declining cardiorespiratory fitness (CRF). High-intensity interval training (HIIT) is time-efficient and improves CRF, but its effects on cardiometabolic health and habitual PA remain controversial, especially with very low-volume protocols like Tabata (4 min/session). This study evaluated a 12-week Tabata-style functional HIIT on cardiometabolic health and PA in female university students.
**Methods:** This 12-week RCT enrolled 122 female freshmen from Ningbo University (March 2022). Exclusion criteria: CVD, diabetes, conditions affecting PA/diet, pregnancy. Final analysis included 59 Tabata and 58 control participants (1 dropout due to hypoglycemia; 4 controls missing post-test blood data). The Tabata group performed 3 supervised sessions/week: 10-min warm-up, 4-min Tabata (8 × 20-s all-out functional exercises [jumping jacks, high knees, squat jumps, mountain climbers] with 10-s rest), 5-min cool-down. Intensity was monitored via Polar H10 HR monitors (target: ≥80% HRmax). Control group maintained routine habits. Measurements included: body composition (bioelectrical impedance), waist circumference (WC), resting HR, blood pressure (BP), VO2max (modified YMCA submaximal cycle test), fasting blood lipids (TC, LDL, HDL, TG), HbA1c, CRP, fasting glucose (FPG), fasting insulin, HOMA-IR, PA (ActiGraph wGT3X-BT accelerometer for 7 days), and dietary intake (FFQ). MetS was defined per Alberti et al. (2009) criteria. Statistical analysis used mixed linear models, Cohen's d effect sizes, and linear regression, controlling for age, lifestyle, baseline values, and changes in body composition, CRF, and diet.
**Key Results:** Exercise fidelity was high: mean HR during exercise = 83.24% (95% CI: 82.75%–83.74%) of HRmax; adherence = 98.31%. Significant intervention effects (Tabata vs. control) were observed for: VO2max (relative: +12.87% vs. −0.27%, p<0.001, d=2.53; absolute: +12.73% vs. +0.98%, p<0.001, d=2.24), resting HR (−8.62% vs. +0.05%, p<0.001, d=−1.82), SBP (−3.66% vs. +0.22%, p<0.001, d=−1.24), %BF (−2.57% vs. +3.23%, p<0.001, d=−1.15), FM (−2.61% vs. +4.58%, p<0.001, d=−1.08), HDL (+8.54% vs. +0.45%, p<0.001, d=1.04), LDL (−1.95% vs. +1.06%, p=0.003, d=−0.57), TC (−1.07% vs. +0.90%, p=0.001, d=−0.64), HOMA-IR (−1.24% vs. +0.24%, p=0.026, d=−0.42), fasting insulin (−0.83% vs. +0.29%, p=0.035, d=−0.40), MVPA (+15.51% vs. −2.95%, p<0.001, d=2.31), and TPA (+14.92% vs. −2.03%, p<0.001, d=1.98). Weight and BMI did not change in the Tabata group but increased in controls (1.25%, p=0.011). DBP, FPG, HbA1c, and CRP showed no significant intervention effects. MetS prevalence decreased from 5.08% to 0% in Tabata (unchanged in controls). Subgroup analysis showed greater improvements in overweight/obese participants: weight (−3.54%, p<0.001), WC (−1.24%, p<0.001), FM (−8.61%, p=0.001), LDL (−8.59%, p<0.001), TG (−6.30%, p=0.007), TC (−4.83%, p<0.001), HbA1c (−0.73%, p=0.008), FPG (−1.50%, p=0.034), HOMA-IR (−3.84%, p=0.009), MVPA (+22.50%, p=0.004), and TPA (+22.84%, p=0.005). Regression analysis showed that changes in TPA (β=0.480, p=0.001) and MVPA (β=0.326, p=0.015) were independently associated with improvements in HDL.
**Clinical Implications:** A 12-week Tabata-style functional HIIT (4 min/session, 3 sessions/week) is a feasible, time-efficient intervention that improves CRF, body composition, SBP, lipid profiles, insulin sensitivity, and habitual PA in female university students. Benefits are most pronounced in overweight/obese individuals, who also showed reductions in weight, WC, and FPG. The protocol achieved high adherence (98.31%) and consistent exercise intensity. The association between increased habitual PA and HDL improvement suggests that HIIT may promote broader lifestyle changes. This low-volume protocol could be implemented in university settings to counteract the rising prevalence of MetS and physical inactivity in young women. Limitations include lack of follow-up, potential dietary confounding, and short duration for assessing clinical outcomes.