This paper argues that while co-design is a useful Western methodology for engaging communities in health service design, it lacks the cultural grounding needed for Indigenous populations. The authors introduce mahitahi, a kaupapa Māori co-design approach grounded in Māori worldviews, values, and knowledge systems, and provide recommendations for researchers and policymakers on navigating between Western and Māori knowledge systems. The clinical significance is that culturally responsive methodologies like mahitahi are essential for addressing persistent health inequities for Māori and other vulnerable populations in Aotearoa/New Zealand.