**Background:** Bioprinting is a rapidly advancing technology that deposits living cells and biomaterials in a precise layer-by-layer manner to fabricate bioengineered constructs. It holds promise for creating personalized tissues and organs, addressing the critical shortage of donor organs, and improving health-related quality of life (HRQoL). This systematic review aims to summarize the potential impact of bioprinting on HRQoL, focusing on benefits such as personalized part production, reduced rejection risks, accelerated skin regeneration, and elimination of the need for organ donors.
**Methods:** The review followed PRISMA guidelines. A comprehensive literature search was conducted in PubMed, Scopus, Google Scholar, and ScienceDirect databases between 2019 and 2023. Keywords included 3D (bio)printing, additive manufacturing, health-related quality of life, tissue engineering, and specific terms like 3D bioprinted joints, cartilage, bone, vasculature, and patient satisfaction. Inclusion criteria were articles published between 2018 and 2023, reviews or systematic reviews, and full-text articles. Exclusion criteria included abstracts, short communications, patents, case reports, and studies lacking fundamental information about additive manufacturing and bioprinting. Three authors independently reviewed abstracts and full texts, reaching consensus on final selection.
**Key Results:** The initial search identified 468 articles; after removing duplicates, 253 remained. Following abstract evaluation, 96 articles were excluded, leaving 157 full papers for analysis. Ultimately, 128 full-text articles were included. The review identified several key potential benefits of bioprinting for HRQoL: personalized part production; saving millions of lives; reducing rejection risks after transplantation; accelerating skin tissue regeneration; homocellular tissue model generation; precise fabrication with accurate specifications; and eliminating the need for organ donors, thereby reducing patient waiting time. Specific examples include: 3D-printed triangular titanium implants for sacroiliac joint fusion showed significant improvements in pain, disability, and quality of life (Patel et al., 2020). In dentistry, 3D-printed templates and resin composites for anterior teeth restoration were found to be convenient, aesthetically pleasing, and functional (Xia et al., 2018). A study on 3D-printed PEEK implants for zygomatic bone deformities demonstrated potential for precise restoration and reduced surgical time (Moiduddin et al., 2023). For cancer treatment, 3D-printed tumor models aid in diagnosis, surgical planning, and personalized drug development. A 3D-bioprinted white adipose tissue model was developed to study cancer-associated cachexia, revealing increased lipolysis and ECM accumulation (151).
**Clinical Implications:** Bioprinting has the potential to revolutionize personalized medicine by enabling the production of patient-specific tissues and organs, reducing reliance on donor programs, and minimizing rejection risks. It can accelerate wound healing and skin regeneration, improve surgical planning and outcomes, and enhance cancer treatment through personalized models and therapies. However, the technology is still in early stages, requiring extensive clinical trials, long-term assessments of patient outcomes, immunological response studies, and economic evaluations (e.g., quality-adjusted life years) to ensure safety, efficacy, and widespread adoption. The paradigm shift from conventional to personalized medicine, driven by bioprinting, is expected to significantly improve HRQoL by reducing pain, improving functionality, and enhancing overall well-being.