A clinician's guide to gallstones and common bile duct (CBD): A study protocol for a systematic review and evidence‐based recommendations

Health Science Reports · 4 authors, 2 centres

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TL;DR

This paper describes a protocol for conducting a systematic review to develop evidence-based clinical guidelines for the diagnosis and management of gallstones and common bile duct stones. The central goal is to synthesize existing evidence from databases and professional societies to provide individualized treatment recommendations.

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The review aims to synthesize evidence on the epidemiology, diagnosis, and management of gallstones, including categorization into cholesterol and pigment types, diagnostic tools like transabdominal ultrasound, and treatments ranging from surgery to oral litholysis. The protocol notes that expert consultations will help localize recommendations.

STUDY TYPE

guidelines

SPECIALTY

gastroenterology

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ORIGINAL PAPER

PMC10496460

A clinician's guide to gallstones and common bile duct (CBD): A study protocol for a systematic review and evidence‐based recommendations

Health Science Reports

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ABSTRACT

Abstract Background and Aims Gallstones are one of the most common and costly diseases of the gastrointestinal tract and occur when a combination of deposits consisting of fat or minerals accumulate in the gallbladder or common bile duct (CBD). This paper provides a comprehensive review of gallstone epidemiology, diagnosis, and management, focusing on current clinical guidelines and evidence‐based approaches. Methods A systematic literature review gathered information from various sources, including PubMed, Trip, Google Scholar, Clinical Key, and reputable medical association websites. Keywords related to gallstones, CBD stones, cholelithiasis, choledocholithiasis, and guidelines were used to extract relevant recommendations. Expert consultations and consensus meetings localized the recommendations based on the target population and available resources. Results The paper discusses demographic factors, dietary habits, and lifestyle influences contributing to gallstone formation. Gallstones are categorized into cholesterol and pigment types, with varying prevalences across regions. Many individuals with gallstones remain asymptomatic, but complications can lead to serious and potentially life‐threatening conditions. Diagnosis relies on history, physical examination, laboratory tests, and transabdominal ultrasound. Specific predictive factors help categorize patients into high, moderate, or low probability groups for CBD stones. Conclusion Evidence‐based recommendations for gallstone diagnosis and management are presented, emphasizing individualized treatment plans. Surgical interventions, nonsurgical treatments like oral litholysis with UDCA, and stenting are discussed. The management of gallstones in pregnant women is also addressed, considering the potential risks and appropriate treatment options during pregnancy. Keywords: bile duct, cholecystectomy, endoscopic, gallbladder, gallstones

CITATION EXPORT

Vahid Sebghatollahi, Mohammadreza Parsa, Mohammad Minakari et al.. A clinician's guide to gallstones and common bile duct (CBD): A study protocol for a systematic review and evidence‐based recommendations. Health Science Reports. (2023). https://doi.org/10.1002/hsr2.1555

AUTHORS

4 · 2 CENTRES

Vahid Sebghatollahi, Mohammadreza Parsa, Mohammad Minakari, Saleh Azadbakht

1 Department of Internal Medicine, School of Medicine, Al‐Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Internal Medicine, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran