A comparative absorption study of sucrosomial ® orodispersible vitamin D3 supplementation vs. a reference chewable tablet and soft gel capsule vitamin D3 in improving circulatory 25(OH)D levels in healthy adults with vitamin D deficiency—Results from a prospective randomized clinical trial
Frontiers in Nutrition · 17 authors, 15 centres
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The sucrosomial formulation resulted in significantly higher and more sustained circulatory vitamin D levels compared to both conventional formulations.
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THE STUDY COMPRISED TWO PARTS
Study 1 randomized 25 subjects to receive weekly 200,000 IU of sucrosomial or chewable tablet vitamin D3 for 3 weeks, with 25(OH)D levels measured after 2, 3, and 6 weeks. Study 2 randomized 20 subjects to receive bi-weekly 200,000 IU of sucrosomial or soft gel capsule vitamin D3 for 6 weeks, with measurements after 4 and 6 weeks. In both studies, circulatory 25(OH)D levels increased significantly in all treatment groups. The treatment was well tolerated, with no adverse events reported. Limitations include the small sample size, open-label design, and lack of diseased participants. The results, validated across two different ethnic groups in Pakistan, suggest efficient absorption of the sucrosomial preparation.
