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TL;DR
The review discusses how collagen is a critical structural protein in the extracellular matrix of intervertebral discs, providing tensile strength and resilience.
Cureus · 6 authors, 1 centre
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The review discusses how collagen is a critical structural protein in the extracellular matrix of intervertebral discs, providing tensile strength and resilience.
The review discusses how collagen is a critical structural protein in the extracellular matrix of intervertebral discs, providing tensile strength and resilience. It posits that genetic variations can influence collagen homeostasis—synthesis, assembly, and degradation—thereby contributing to the susceptibility and progression of IVDD. The central conclusion is that understanding these genetic factors offers deeper insight into IVDD pathogenesis and may inform future targeted therapeutic interventions and personalized medicine approaches.