SEARCHNARRATIVE_REVIEWnutrition, clinical nutrition

narrative_review·nutrition, clinical nutrition, cardiology, neurology, preclinical research·PMC10353157

A comprehensive review of the health benefits of flaxseed oil in relation to its chemical composition and comparison with other omega-3-rich oils

European Journal of Medical Research · 5 authors, 4 centres

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TL;DR

This narrative review synthesizes evidence from 112 papers on the health benefits of flaxseed oil, attributing its therapeutic effects primarily to its high content of α-linolenic acid (ALA) and linoleic acid.

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503 CHARS

This narrative review searched Web of Science, PubMed, and Scopus for studies on flaxseed oil biological effects including antioxidant, anti-inflammatory, antimicrobial, anticancer, antiulcer, anti-osteoporotic, cardioprotective, neuroprotective, and metabolic syndrome outcomes, ultimately citing 112 papers. ALA is described as having anti-inflammatory effects via decreasing production of inflammatory cytokines, and the oil's PUFA content is attributed to immunoregulatory and antibacterial effects.

STUDY TYPE

narrative_review

SPECIALTY

nutrition

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100% · A

ORIGINAL PAPER

PMC10353157

A comprehensive review of the health benefits of flaxseed oil in relation to its chemical composition and comparison with other omega-3-rich oils

European Journal of Medical Research

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ABSTRACT

Flaxseed ( Linum usitatissimum L) is an ancient perennial plant species regarded as a multipurpose plant owing to its richness in omega-3 polyunsaturated fatty acids (PUFA) including α-linolenic acid (ALA). The extensive biochemical analysis of flaxseed resulted in the identification of its bioactive, i.e., lignans with potential application in the improvement of human health. Flaxseed oil, fibers, and lignans exert potential health benefits including reduction of cardiovascular disease, atherosclerosis, diabetes, cancer, arthritis, osteoporosis, and autoimmune and neurological disorders that have led to the diversification of flaxseed plant applications. This comprehensive review focuses on flaxseed oil as the major product of flaxseed with emphasis on the interrelationship between its chemical composition and biological effects. Effects reviewed include antioxidant, anti-inflammatory, antimicrobial, anticancer, antiulcer, anti-osteoporotic, cardioprotective, metabolic, and neuroprotective. This study provides an overview of flaxseed oil effects with the reported action mechanisms related to its phytochemical composition and in comparison, to other PUFA-rich oils. This study presents the most updated and comprehensive review summarizing flaxseed oil’s health benefits for the treatment of various diseases. Graphical Abstract

CITATION EXPORT

Somaia Al-Madhagy, Naglaa S. Ashmawy, Ayat Mamdouh et al.. A comprehensive review of the health benefits of flaxseed oil in relation to its chemical composition and comparison with other omega-3-rich oils. European Journal of Medical Research. (2023). https://doi.org/10.1186/s40001-023-01203-6

AUTHORS

5 · 4 CENTRES

Somaia Al-Madhagy, Naglaa S. Ashmawy, Ayat Mamdouh, Omayma A. Eldahshan, Mohamed A. Farag

1grid.7776.10000 0004 0639 9286Pharmacognosy Department, College of Pharmacy, Cairo University, Kasr El-Aini St., Cairo, 11562 Egypt
2grid.7269.a0000 0004 0621 1570Pharmacognosy Department, Faculty of Pharmacy, Ain Shams University, Cairo, 11566 Egypt
3grid.7155.60000 0001 2260 6941Faculty of Pharmacy, Alexandria University, Alexandria, Egypt
4grid.7269.a0000 0004 0621 1570Present Address: Center of Drug Discovery Research and Development, Ain Shams University, Cairo, 11566 Egypt