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TL;DR
This narrative review synthesizes in vitro and in vivo evidence on apigenin's anticancer effects in colorectal cancer.
Food Science & Nutrition · 9 authors, 13 centres
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This narrative review synthesizes in vitro and in vivo evidence on apigenin's anticancer effects in colorectal cancer.
This narrative review summarizes preclinical in vitro and in vivo studies investigating apigenin, a naturally occurring flavonoid, against colorectal cancer. Apigenin was shown to suppress the cell cycle in the G2/M phase and to promote apoptosis while inhibiting autophagy formation in colorectal cancer cells. However, the authors acknowledge that pharmacology and pharmacokinetic research is still needed before apigenin can be evaluated in clinical studies, and no human trial data are included.