A non-pharmacological multidomain intervention of dual-task exercise and social activity affects the cognitive function in community-dwelling older adults with mild to moderate cognitive decline: A randomized controlled trial

Frontiers in Aging Neuroscience · 8 authors, 6 centres

AI SUMMARY

FIDELITY 100%

POPULATIONCommunity-dwelling older adults aged ≥70 years with mild to moderate cognitive decline (MMSE 21-24)

INTERVENTIONMultidomain intervention with dual-task exercise and social activity over 10 months

COMPARISONEducation program (control group)

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

“

TL;DR

This RCT tested a 10-month multidomain intervention combining dual-task exercise and social activity in older adults with mild to moderate cognitive decline. The intervention significantly improved logical memory recognition and physical function, but the short follow-up and lack of effect on other cognitive domains limit long-term conclusions.

Full summary

1,519 CHARS

BACKGROUND

Cognitive decline in older adults is a growing concern, and multidomain interventions combining physical and cognitive activities may offer benefits. Methods: This RCT involved 280 community-dwelling older adults (mean age 76.4 years) with mild to moderate cognitive decline (MMSE 21-24). Participants were randomized to an intervention group (dual-task exercise and social activities) or control group (education program) for 10 months. Assessments included cognitive function (NCGG-FAT), physical function (grip strength, 5CS, walking speed, 6MWT), social engagements, and accelerometer data. Statistical analysis used repeated-measures ANCOVA with intention-to-treat and per-protocol approaches. Key Results: The intervention group showed significant improvement in logical memory recognition (p=0.026) compared to control. Additionally, improvements were seen in 6-minute walk test (p<0.001), daily steps (p=0.005), and moderate-to-vigorous physical activity (p=0.033). No significant differences were found in other cognitive domains such as attention or executive function. Limitations: The 10-month follow-up may be too short to assess long-term dementia prevention; the intervention did not improve all cognitive areas; and genetic factors were not considered. Implications: This multidomain intervention may enhance cognitive and physical function in older adults with cognitive decline, suggesting potential for delaying dementia progression, but further research is needed for long-term outcomes.

PICO

PPOPULATION

Community-dwelling older adults aged ≥70 years with mild to moderate cognitive decline (MMSE 21-24)

IINTERVENTION

Multidomain intervention with dual-task exercise and social activity over 10 months

OOUTCOME

Cognitive function (logical memory recognition), physical function (6MWT, daily steps), social engagements

STUDY TYPE

RCT

SPECIALTY

geriatrics

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10040752

A non-pharmacological multidomain intervention of dual-task exercise and social activity affects the cognitive function in community-dwelling older adults with mild to moderate cognitive decline: A randomized controlled trial

Frontiers in Aging Neuroscience

READ THE FULL PAPER

JUMP TO SECTION

ABSTRACT

Abstract The present study aimed to determine the impact of a 10-month multidomain program using dual-task exercise and social activity conducted at a community-based facility on improved cognitive function in older adults with mild to moderate cognitive decline. The participants included 280 community-dwelling older adults (age 71–91 years) with mild to moderate cognitive decline. The intervention group exercised for 90 min/day, once a week. Their routine included aerobic exercise and dual-task training which cognitive tasks were performed in combination with exercise. The control group attended health education classes thrice. Before and after the intervention, we measured their cognitive function, physical function, daily conversation, and physical activity. The mean adherence rate of the intervention class was 83.0%. According to a repeated-measures multivariate analysis of covariance in an intent-to-treat analysis, logical memory and 6-min walking distance demonstrated a significant time and group interaction effect. Regarding daily physical activities, we observed significant differences in the daily step count and moderate-to-vigorous physical activity in the intervention group. Our non-pharmacological multidomain intervention resulted in a modest improvement in the cognitive or physical function and building health behavior. It may be a helpful program with a potential role in preventing dementia. Clinical Trial Registration : http://clinicaltrials.gov Identifier ID: UMIN000013097. Keywords: non-pharmacological multi-domain program, dual task, community-dwelling older adults, cognitive decline, randomized control trial, geriatric health

CITATION EXPORT

Sangyoon Lee, Kenji Harada, Seongryu Bae et al.. A non-pharmacological multidomain intervention of dual-task exercise and social activity affects the cognitive function in community-dwelling older adults with mild to moderate cognitive decline: A randomized controlled trial. Frontiers in Aging Neuroscience. (2023). https://doi.org/10.3389/fnagi.2023.1005410

AUTHORS

8 · 6 CENTRES

Sangyoon Lee, Kenji Harada, Seongryu Bae, Kazuhiro Harada, Keitaro Makino, Yuya Anan, Takao Suzuki, Hiroyuki Shimada

1Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu, Japan
2Department of Health Care and Science, Dong-A University, Busan, Republic of Korea
3Graduate School of Human Development and Environment, Kobe University, Kobe, Hyogo, Japan
4Japan Society for the Promotion of Science, Tokyo, Japan
5Kwassui Women’s University, Nagasaki, Japan
6Institute for Aging and Development, J. F. Oberlin University, Machida, Japan