Life · 12 authors, 7 centres
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This pilot analysis from a randomized trial of 70 pregnant women with pregestational diabetes found that certain phenotypic factors, such as black skin color and high blood pressure early in pregnancy, were associated with an increased risk of developing hypertensive disorders, while diet and specific genetic variants were not.
This pilot analysis was a nutrigenetic trial of 70 pregnant women with pregestational diabetes in Brazil, randomized to a traditional or DASH diet. The study assessed dietetic, phenotypic, and genotypic factors influencing hypertensive disorders of pregnancy (HDP). Phenotypic risk factors for HDP progression included black skin color (aHR 8.63, p=0.01), a history of preeclampsia (aHR 11.66, p<0.01), and specific blood pressure and glycemic thresholds. Diet and genotypic features (FTO and ADRB2 polymorphisms) showed no significant effect on HDP risk, though statistical power was limited.
