A Possible Mechanism of Erectile Dysfunction in Coronavirus Disease-19: Cavernosal Smooth Muscle Damage: A Pilot Study

Revista Internacional De Andrologia · 7 authors, 1 centre

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TL;DR

It found that patients hospitalized for COVID-19 had significantly lower smooth muscle amplitudes and relaxation capacity compared to a control group without COVID-19.

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The primary finding was that pre-vasoactive-drug amplitudes on cc-EMG were significantly lower in both COVID-19 groups compared to the control group (p=0.005 for hospitalized vs. control). No significant differences were found between groups in hormonal profiles or penile CDUS findings.

STUDY TYPE

case-control

SPECIALTY

internal medicine

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100% · A

ORIGINAL PAPER

PMC10261716

A Possible Mechanism of Erectile Dysfunction in Coronavirus Disease-19: Cavernosal Smooth Muscle Damage: A Pilot Study

Revista Internacional De Andrologia

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ABSTRACT

Introduction Studies have reported that COVID-19 may cause erectile dysfunction (ED), however, its role in the pathophysiology of ED has not yet been fully elucidated. We aimed to elucidate COVID-19's effects on cavernosal smooth muscle, which has a pretty important role in erection physiology, by corpus cavernosum electromyography (cc-EMG). Materials and Methods Twenty-nine male patients aged 20-50 years who applied to the urology outpatient clinic due to ED were included in the study. Nine patients that had COVID-19 and were treated as outpatients were classified as group 1, 10 patients who were hospitalized due to COVID-19 were classified as group 2, and 10 patients who did not have COVID-19 were classified as the control group (group 3). Patients underwent diagnostic evaluation including International Index of Erectile Function (IIEF)-5 form, penile color Doppler ultrasonography (CDUS), cc-EMG, and fasting serum levels of reproductive hormones (07-11 am). Results According to penile CDUS and hormonal values results, there was no significant difference between the groups. According to cc-EMG results, amplitudes and relaxation capacities of the cavernosal smooth muscle EMG activities of patients in group 3 were significantly higher than those in the other groups. Conclusions COVID-19 can cause ED not only by psychogenic and hormonal factors but also with cavernosal smooth muscle damage.

CITATION EXPORT

Selman Unal, Halil Uzundal, Turker Soydas et al.. A Possible Mechanism of Erectile Dysfunction in Coronavirus Disease-19: Cavernosal Smooth Muscle Damage: A Pilot Study. Revista Internacional De Andrologia. (2023). https://doi.org/10.1016/j.androl.2023.100366

AUTHORS

7 · 1 CENTRES

Selman Unal, Halil Uzundal, Turker Soydas, Musab A. Kutluhan, Asim Ozayar, Emrah Okulu, Onder Kayigil

Department of Urology, Ankara Yildirim Beyazit University School of Medicine, Ankara, Turkey