Future Science OA · 10 authors, 11 centres
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This narrative review describes the classification and physicochemical properties of various nanoparticles, including RNA-based nanostructures, for potential use in therapeutic drug and gene delivery. It concludes that while RNA nanotechnology shows promise, particularly for cancer targeting, significant challenges like delivery efficiency and endosomal escape must be overcome before clinical realization.
It highlights the theoretical benefits of RNA nanotechnology, including polyvalent delivery and optimal nanoscale size for improved pharmacokinetics and tissue retention. The review identifies key obstacles, such as RNA instability, manufacturing costs, and the need for improved endosomal escape, and discusses potential solutions like chemical modifications. It concludes that while RNA nanotechnology has improved cancer targeting in preclinical contexts, further research is required to boost delivery efficiency and specificity before clinical translation can be achieved.
