BMC Genomics · 5 authors, 4 centres
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Researchers developed an immune-related gene pair signature from TCGA data and validated it across three GEO datasets. The signature successfully stratified esophageal cancer patients into high- and low-risk groups with significantly different overall survival outcomes.
This retrospective cohort study developed a 21 immune-related gene pair (IRGP) prognostic signature using the TCGA esophageal cancer cohort and validated it across three independent GEO datasets. The signature, based on 38 genes, classified patients into high- and low-risk groups. Kaplan-Meier analysis showed significantly worse overall survival for high-risk patients in the training and validation sets. Multivariate Cox analysis confirmed the signature as an independent prognostic factor. Immune cell infiltration analysis revealed significant differences in plasma cells and activated CD4 memory T cells between risk groups. In vitro qRT-PCR validated the expression of six selected genes in KYSE-150 and KYSE-450 cell lines. Limitations include the small sample size of 479 patients and the retrospective nature of the analysis, requiring prospective validation.
