Addiction Biology · 4 authors, 3 centres
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This systematic review of 20 studies found that acute THC consumption selectively impairs oculomotor control by increasing saccadic latency and inaccuracy while impairing inhibitory control, and that chronic cannabis users display enduring oculomotor deficits affecting visual scanning efficiency.
This PRISMA-guided systematic review synthesised 20 articles comprising 12 experimental acute dosing trials, 5 cross-sectional chronic use studies, and 3 roadside epidemiological studies examining cannabis/THC effects on oculomotor behaviour relevant to driving. Acute THC consumption selectively impaired oculomotor control, notably increasing saccadic latency and inaccuracy and impairing inhibitory control. Chronic cannabis users, particularly those with early onset of use, displayed enduring oculomotor deficits affecting visual scanning efficiency. Eyelid tremors were consistently observed with cannabis use but appeared unlikely to be directly linked with behavioural impairment. Smooth pursuit reductions were inconsistent across studies. The review's inclusion of diverse study designs and marked heterogeneity precluded meta-analysis and methodological cross-comparisons.
