eNeuro · 4 authors, 1 centre
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Etv1 knockout mice lacking Etv1 in taste cells showed markedly decreased chorda tympani nerve responses to sweet, umami, and amiloride-sensitive salty tastes but unchanged responses to bitter and sour tastes. The study demonstrates that the transcription factor Etv1 participates in the differentiation of Skn-1a-dependent sweet, umami, and sodium taste cells.
Molecular analyses, gene expression profiling, and chorda tympani nerve electrophysiology were employed. Knockout mice lacked Etv1 expression in taste cells but retained normal Skn-1a-dependent cell populations, with regionally altered gene expression in taste cells. Electrophysiological recordings revealed markedly decreased chorda tympani nerve responses to sweet, umami, and amiloride-sensitive sodium tastes in knockout mice, while bitter and sour taste responses were unchanged. These findings indicate Etv1 regulates differentiation of specific taste cell lineages by controlling taste receptor gene expression, distinguishing sweet, umami, and sodium cells from bitter cells among Skn-1a-dependent progenitors.
