SEARCHNARRATIVE_REVIEWneurology, minerals

narrative_review·neurology, minerals, preclinical research, systematic review, meta-analysis·PMC10525645

Abnormalities in Copper Status Associated with an Elevated Risk of Parkinson’s Phenotype Development

Antioxidants · 5 authors, 6 centres

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The paper synthesizes findings from human observational studies, genetic research, and mammalian/C. elegans models.

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The paper synthesizes findings from human observational studies, genetic research, and mammalian/C. elegans models. The review highlights that copper status markers like holo-ceruloplasmin may be valuable prognostic markers for PD subtypes. Implications suggest that measuring copper status markers could be important in PD diagnosis and prognosis.

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narrative_review

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neurology

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ORIGINAL PAPER

PMC10525645

Abnormalities in Copper Status Associated with an Elevated Risk of Parkinson’s Phenotype Development

Antioxidants

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ABSTRACT

Abstract In the last 15 years, among the many reasons given for the development of idiopathic forms of Parkinson’s disease (PD), copper imbalance has been identified as a factor, and PD is often referred to as a copper-mediated disorder. More than 640 papers have been devoted to the relationship between PD and copper status in the blood, which include the following markers: total copper concentration, enzymatic ceruloplasmin (Cp) concentration, Cp protein level, and non-ceruloplasmin copper level. Most studies measure only one of these markers. Therefore, the existence of a correlation between copper status and the development of PD is still debated. Based on data from the published literature, meta-analysis, and our own research, it is clear that there is a connection between the development of PD symptoms and the number of copper atoms, which are weakly associated with the ceruloplasmin molecule. In this work, the link between the risk of developing PD and various inborn errors related to copper metabolism, leading to decreased levels of oxidase ceruloplasmin in the circulation and cerebrospinal fluid, is discussed. Keywords: Parkinson’s disease, serum copper level, serum ceruloplasmin, cerebrospinal fluid, meta-analysis

CITATION EXPORT

Marina N Karpenko, Zamira M Muruzheva, Ekaterina Yu Ilyechova et al.. Abnormalities in Copper Status Associated with an Elevated Risk of Parkinson’s Phenotype Development. Antioxidants. (2023). https://doi.org/10.3390/antiox12091654

AUTHORS

5 · 6 CENTRES

Marina N Karpenko, Zamira M Muruzheva, Ekaterina Yu Ilyechova, Polina S Babich, Ludmila V Puchkova

1I.P. Pavlov Department of Physiology, Research Institute of Experimental Medicine, 197376 St. Petersburg, Russia; [email protected] (M.N.K.); [email protected] (Z.M.M.)
2Institute of Biomedical Systems and Biotechnology, Peter the Great St. Petersburg Polytechnic University, 195251 St. Petersburg, Russia; [email protected]
3State Budgetary Institution of Health Care “Leningrad Regional Clinical Hospital”, 194291 St. Petersburg, Russia
4Research Center of Advanced Functional Materials and Laser Communication Systems, ADTS Institute, ITMO University, 197101 St. Petersburg, Russia
5Department of Molecular Genetics, Research Institute of Experimental Medicine, 197376 St. Petersburg, Russia
6Department of Zoology and Genetics, Faculty of Biology, Herzen State Pedagogical University of Russia, 191186 St. Petersburg, Russia; [email protected]