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other·ophthalmology, retina, neurology, preclinical research, biomedical research·PMC10487815

Acrolein Induces Retinal Abnormalities of Alzheimer’s Disease in Mice

International Journal of Molecular Sciences · 6 authors, 5 centres

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TL;DR

Researchers induced a mouse model of sporadic Alzheimer's disease using acrolein and found retinal changes resembling those in human AD, including increased Aβ and p-Tau, reduced retinal nerve fiber layer thickness, and decreased ERG b-wave amplitudes.

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This preclinical study investigated retinal abnormalities in a mouse model of sporadic Alzheimer's disease (sAD) induced by intragastric acrolein. C57BL/6 mice were administered acrolein or served as controls. No significant changes in intraocular pressure were found. A later-stage retinal vascular abnormality, slight venous beading, was observed at 3 months. Implications suggest that acrolein-induced sAD mice exhibit early retinal pathology, providing a model to study retina-brain connections in sAD.

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other

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ophthalmology

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ORIGINAL PAPER

PMC10487815

Acrolein Induces Retinal Abnormalities of Alzheimer’s Disease in Mice

International Journal of Molecular Sciences

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ABSTRACT

It is reported that retinal abnormities are related to Alzheimer’s disease (AD) in patients and animal models. However, it is unclear whether the retinal abnormities appear in the mouse model of sporadic Alzheimer’s disease (sAD) induced by acrolein. We investigated the alterations of retinal function and structure, the levels of β-amyloid (Aβ) and phosphorylated Tau (p-Tau) in the retina, and the changes in the retinal vascular system in this mouse model. We demonstrated that the levels of Aβ and p-Tau were increased in the retinas of mice from the acrolein groups. Subsequently, a decreased amplitudes of b-waves in the scotopic and photopic electroretinogram (ERG), decreased thicknesses of the retinal nerve fiber layer (RNFL) in the retina, and slight retinal venous beading were found in the mice induced by acrolein. We propose that sAD mice induced by acrolein showed abnormalities in the retina, which may provide a valuable reference for the study of the retina in sAD.

CITATION EXPORT

Shuyi Wang, Xiuying Jiang, Weijia Peng et al.. Acrolein Induces Retinal Abnormalities of Alzheimer’s Disease in Mice. International Journal of Molecular Sciences. (2023). https://doi.org/10.3390/ijms241713576

AUTHORS

6 · 5 CENTRES

Shuyi Wang, Xiuying Jiang, Weijia Peng, Shuangjian Yang, Rongbiao Pi, Shiyou Zhou

1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China
2Department of Ophthalmology, Affiliated Foshan Hospital, Southern Medical University, Foshan 528000, China
3School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
4Guangdong Provincial Institute for Vision and Eye Research, Guangzhou 510060, China
5School of Medicine, Sun Yat-sen University, Shenzhen 528406, China