JPGN Reports · 6 authors, 1 centre
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This case report describes a newborn with acute liver failure secondary to neonatal lupus erythematosus, who was successfully treated with a novel protocol of exchange transfusion, intravenous immunoglobulin (IVIG), and steroids, leading to full recovery.
The report details a term-born female infant who developed acute liver failure on day of life 18, with elevated INR and liver enzymes, in the context of maternal anti-Ro antibody-positive systemic lupus erythematosus and cutaneous neonatal lupus. The authors propose that this approach, modeled on treatment for gestational alloimmune liver disease, effectively halted antibody-mediated injury. Limitations include the single-case nature and absence of a liver biopsy for definitive histologic confirmation.
