Adipose stem cells in tissue regeneration and repair: From bench to bedside

Regenerative Therapy · 9 authors, 4 centres

AI SUMMARY

FIDELITY 100%

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

“

TL;DR

Methods to enhance ADSC efficacy, including preconditioning with neurotrophic factors, hypoxic culture, and co-culture strategies, are discussed.

Full summary

145 CHARS

Methods to enhance ADSC efficacy, including preconditioning with neurotrophic factors, hypoxic culture, and co-culture strategies, are discussed.

STUDY TYPE

narrative_review

SPECIALTY

preclinical research

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10579872

Adipose stem cells in tissue regeneration and repair: From bench to bedside

Regenerative Therapy

READ THE FULL PAPER

ABSTRACT

Abstract ADSCs are a large number of mesenchymal stem cells in Adipose tissue, which can be applied to tissue engineering. ADSCs have the potential of multi-directional differentiation, and can differentiate into bone tissue, cardiac tissue, urothelial cells, skin tissue, etc. Compared with other mesenchymal stem cells, ADSCs have a multitude of promising advantages, such as abundant number, accessibility in cell culture, stable function, and less immune rejection. There are two main methods to use ADSCs for tissue repair and regeneration. One is to implant the “ADSCs-scaffold composite” into the injured site to promote tissue regeneration. The other is cell-free therapy: using ADSC-exos or ADSC-CM alone to release a large number of miRNAs, cytokines and other bioactive substances to promote tissue regeneration. The tissue regeneration potential of ADSCs is regulated by a variety of cytokines, signaling molecules, and external environment. The differentiation of ADSCs into different tissues is also induced by growth factors, ions, hormones, scaffold materials, physical stimulation, and other factors. The specific mechanisms are complex, and most of the signaling pathways need to be further explored. This article reviews and summarizes the mechanism and clinical application of ADSCs in tissue injury repair so far, and puts forward further problems that need to be solved in this field, hoping to provide directions for further research in this field. Keywords: ADSCs, Exosomes, Tissue repair, Mechanism

CITATION EXPORT

Lei Dong, Xiaoyu Li, Wenyuan Leng et al.. Adipose stem cells in tissue regeneration and repair: From bench to bedside. Regenerative Therapy. (2023). https://doi.org/10.1016/j.reth.2023.09.014

AUTHORS

9 · 4 CENTRES

Lei Dong, Xiaoyu Li, Wenyuan Leng, Zhenke Guo, Tianyu Cai, Xing Ji, Chunru Xu, Zhenpeng Zhu, Jian Lin

aDepartment of Urology, Peking University First Hospital, Beijing, 100034, China
bInstitute of Urology, Peking University, Beijing, 100034, China
cNational Urological Cancer Center, Beijing, 100034, China
dBeijing Key Laboratory of Urogenital Diseases (male) Molecular Diagnosis and Treatment Center, Beijing, 100034, China