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TL;DR
The primary study used adipose-specific Glut4 overexpression (AG4OX) mice, which show 8- to 16-fold elevation of FAHFA levels in white adipose tissue, and wild-type mice to build an FAHFA biosynthetic assay in adipocytes.
Life Metabolism · 3 authors, 3 centres
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The primary study used adipose-specific Glut4 overexpression (AG4OX) mice, which show 8- to 16-fold elevation of FAHFA levels in white adipose tissue, and wild-type mice to build an FAHFA biosynthetic assay in adipocytes.
The primary study used adipose-specific Glut4 overexpression (AG4OX) mice, which show 8- to 16-fold elevation of FAHFA levels in white adipose tissue, and wild-type mice to build an FAHFA biosynthetic assay in adipocytes. AG4OX adipocytes exhibited a 2-fold increase in 9-C17:1-HSA compared to wild-type. The transacylase and lipase activities of ATGL appear intertwined, as both require co-activator CGI-58 and are blocked by the lipase inhibitor atglistatin.