Adult zebrafish infected by clinically isolated Klebsiella pneumoniae with different virulence showed increased intestinal inflammation and disturbed intestinal microbial biodiversity
BMC Infectious Diseases · 8 authors, 5 centres
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Adult zebrafish were infected with three clinically isolated Klebsiella pneumoniae strains to study intestinal effects. The study found that infection increased intestinal inflammation and disturbed microbial biodiversity.
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This preclinical study used adult zebrafish as a model to assess the intestinal impact of three clinically isolated Klebsiella pneumoniae strains with varying virulence and resistance profiles. The study found that infection with all three strains significantly increased intestinal levels of inflammatory cytokines IL-1α, IL-1β, and TNF-α. Histopathological examination revealed intestinal lesions, with the high-virulence strain KP1053 causing a significant decrease in goblet cells and the KP1195 strain causing epithelial dissolution. 16S rRNA sequencing demonstrated that infection disturbed the intestinal microbiota composition, increasing the Shannon diversity index and the abundance of potentially harmful bacteria like Cyanobacteria.
