SEARCHNARRATIVE_REVIEWinfectious disease, biomedical research

narrative_review·infectious disease, biomedical research, preclinical research, systematic review·PMC10143917

Advances in Natural Products from the Marine-Sponge-Associated Microorganisms with Antimicrobial Activity in the Last Decade

Marine Drugs · 9 authors, 3 centres

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AGENT 01 · STRUCTURED SUMMARY

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TL;DR

This narrative review summarizes 270 secondary metabolites with antimicrobial activity isolated from marine-sponge-associated microorganisms between 2012 and 2022. The central finding is that these compounds, primarily from fungi, show potential as new antimicrobial agents, with 124 being newly discovered and 55 exhibiting both antibacterial and antifungal activity.

Full summary

525 CHARS

The compounds include polyketides, alkaloids, peptides, and terpenoids. The review highlights their in vitro antimicrobial activity against various pathogenic strains and notes 124 are new compounds, with 55 having dual antibacterial and antifungal activity. It discusses structure-activity relationships, potential molecular targets, and preliminary drug-likeness and pharmacokinetic profiles for a few compounds. The work provides a theoretical basis for developing new antimicrobial drugs to address antibiotic resistance.

STUDY TYPE

narrative_review

SPECIALTY

infectious disease

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10143917

Advances in Natural Products from the Marine-Sponge-Associated Microorganisms with Antimicrobial Activity in the Last Decade

Marine Drugs

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ABSTRACT

Microorganisms are the dominating source of food and nutrition for sponges and play an important role in sponge structure, chemical defense, excretion and evolution. In recent years, plentiful secondary metabolites with novel structures and specific activities have been identified from sponge-associated microorganisms. Additionally, as the phenomenon of the drug resistance of pathogenic bacteria is becoming more and more common, it is urgent to discover new antimicrobial agents. In this paper, we reviewed 270 secondary metabolites with potential antimicrobial activity against a variety of pathogenic strains reported in the literature from 2012 to 2022. Among them, 68.5% were derived from fungi, 23.3% originated from actinomycetes, 3.7% were obtained from other bacteria and 4.4% were discovered using the co-culture method. The structures of these compounds include terpenoids (13%), polyketides (51.9%), alkaloids (17.4%), peptides (11.5%), glucosides (3.3%), etc. Significantly, there are 124 new compounds and 146 known compounds, 55 of which have antifungal activity in addition to antipathogenic bacteria. This review will provide a theoretical basis for the further development of antimicrobial drugs.

CITATION EXPORT

Jiaqi Liang, Jianglian She, Jun Fu et al.. Advances in Natural Products from the Marine-Sponge-Associated Microorganisms with Antimicrobial Activity in the Last Decade. Marine Drugs. (2023). https://doi.org/10.3390/md21040236

AUTHORS

9 · 3 CENTRES

Jiaqi Liang, Jianglian She, Jun Fu, Jiamin Wang, Yuxiu Ye, Bin Yang, Yonghong Liu, Xuefeng Zhou, Huaming Tao

1CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, [email protected] (B.Y.); [email protected] (Y.L.)
2University of Chinese Academy of Sciences, Beijing 100049, China
3Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China

EDITOR / REVIEWER

Tatiana V. Ovchinnikova