Scientific Reports · 5 authors, 4 centres
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This study developed and tested a collagen-based tubular graft with autologous urothelial micrografts for potential single-staged urogenital reconstruction. The construct was successfully implanted as a bladder conduit in a minipig model, showing good host integration and urothelial regeneration after three weeks.
The researchers designed a collagen-based scaffold reinforced with a mesh and stent, incorporating porcine urothelial micrografts. 80%), finding that 80% collagen provided better barrier function and less permeability. Biomechanical tests showed the scaffold was stronger than native urethra but weakened over four weeks. The optimized construct was implanted as a bladder conduit in a minipig. Surgical implantation was feasible within routine operating time, and the animal recovered well. Three weeks post-implantation, the conduit showed good integration with a multilayered luminal urothelium. Limitations include the small-scale, preclinical nature of the study, the use of a minipig model, and the lack of assessment for conduit stenosis. The findings support the feasibility of this single-staged approach for further preclinical study.
