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TL;DR
This retrospective study used a modified Global Trigger Tool to identify adverse drug events (ADEs) in 480 elderly Chinese inpatients, finding an ADE incidence of 10.62% and that the number of medicines was a significant risk factor.
Frontiers in Medicine · 9 authors, 4 centres
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This retrospective study used a modified Global Trigger Tool to identify adverse drug events (ADEs) in 480 elderly Chinese inpatients, finding an ADE incidence of 10.62% and that the number of medicines was a significant risk factor.
This retrospective cohort study evaluated a modified Global Trigger Tool for detecting adverse drug events (ADEs) in elderly Chinese inpatients. Researchers identified 56 ADEs in 51 of 480 patients, yielding an incidence of 10.62%, or 13.04 per 1,000 patient days. The overall positive predictive value of the triggers was 23.84%. The majority of ADEs (94.64%) caused temporary injury, with gastrointestinal system injury (27.87%) and metabolic disorders (24.53%) being the most common organ systems affected. Drugs for cardiovascular diseases were the primary cause. Risk factor analysis revealed a significant correlation between the number of medicines and ADE occurrence. Limitations include a single-center design, a sample size that may limit statistical power for other risk factors, and exclusion of certain high-risk patient groups like those with malignant tumors. The study suggests the GTT is a useful tool for enhancing medication safety management in elderly populations.