SEARCHCOHORTpublic health, epidemiology

cohort·public health, epidemiology, immunology, infectious disease, family medicine·PMC10021916

Adverse events following COVID-19 vaccination in Kwara State, North-central Nigeria

PLOS Global Public Health · 9 authors, 8 centres

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AGENT 01 · STRUCTURED SUMMARY

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TL;DR

The incidence of reported adverse events was 1.6%, with 81.1% classified as mild and no fatal outcomes reported.

Full summary

439 CHARS

The incidence of reported adverse events was 1.6% (95 individuals). Most adverse events were systemic (95.8%) and mild (81.1%), with headache (51.6%), fever (49.5%), and generalized body weakness (40.7%) being the most common reactions. No fatal outcomes were reported, and 98.9% of cases achieved full resolution. No significant association was found between age, gender, vaccine dose, or time to onset and adverse event type or severity.

STUDY TYPE

cohort

SPECIALTY

public health

SUMMARISED BY

AI pipeline

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100% · A

ORIGINAL PAPER

PMC10021916

Adverse events following COVID-19 vaccination in Kwara State, North-central Nigeria

PLOS Global Public Health

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ABSTRACT

Abstract Safe and effective vaccination remains the mainstay of control of COVID-19 because there is still no universally recommended treatment. This strategy is however being threatened by vaccine hesitancy and resistance due to fear of adverse events and safety concerns. It is, therefore, necessary to study post-vaccination adverse events (AE) in various populations and geographical areas. The objective of this study was to analyze the adverse events following COVID-19 vaccination in five major immunization centers of Kwara State Nigeria. A retrospective descriptive study of the adverse events following AstraZeneca COVID-19 vaccination that were reported from five immunization centers of Kwara State, North-central Nigeria from March to July 2021 was carried out. Statistical Package for Social Science version 26 was used for analysis. Adverse event classification and severity were compared based on age, gender, and time to onset of adverse event and vaccine dose type using the Chi-square test. The incidence of COVID-19 vaccine AE was 1.6%. There was female predominance (51.6%) and a mean age of 41.6±13.7 years. Most of the AE (95.8%) were systemic and mild (81.1%) without a requirement for any therapeutic intervention. Fatal outcome was not reported in any of the AE and the time to outcome of AE was 2 days in most cases (45.3%). No significant association was found between the variables studied and the adverse event type and severity. The low incidence and mild nature of adverse events reported in this study will add to the body of knowledge regarding vaccine adverse events and may eventually impact vaccine uptake.

CITATION EXPORT

Louis Okeibunor Odeigah, Yahkub Babatunde Mutalub, Olalekan Ayodele Agede et al.. Adverse events following COVID-19 vaccination in Kwara State, North-central Nigeria. PLOS Global Public Health. (2022). https://doi.org/10.1371/journal.pgph.0000835

AUTHORS

9 · 8 CENTRES

Louis Okeibunor Odeigah, Yahkub Babatunde Mutalub, Olalekan Ayodele Agede, Ismail A Obalowu, Susan Aiyetoro, Gafar A A Jimoh, Abram L Wagner, Abram L Wagner, Abram L Wagner

1Department of Family Medicine, College of Health Science University of Ilorin, Ilorin, Kwara State, Nigeria
2Department of Clinical Pharmacology and Therapeutics, College of Medical Sciences, Abubakar Tafawa Balewa University, Bauchi, Nigeria
3Department of Family Medicine Abubakar Tafawa Balewa University Teaching Hospital, Bauchi, Nigeria
4Department of Pharmacology and Therapeutics University of Ilorin, Ilorin, Nigeria
5Department of Family Medicine, General Hospital Ilorin, Ilorin, Kwara State, Nigeria
6Department of Pharmacy and Zonal Pharmacovigilance Center, University of Ilorin Teaching Hospital, Ilorin, Nigeria
7Department of Obstetrics and Gynaecology, University of Ilorin, Ilorin, Nigeria
8University of Michigan, UNITED STATES