SEARCHCOHORTepidemiology, public health

cohort·epidemiology, public health, cardiology, oncology, internal medicine·PMC10287564

Alcohol consumption and risks of more than 200 diseases in Chinese men

Nature Medicine · 20 authors, 29 centres

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TL;DR

This large prospective cohort study of Chinese adults found that alcohol consumption was associated with a higher risk of 61 diseases in men, including 33 not previously recognized as alcohol-related by the WHO.

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Notably, 33 of these were not previously classified as alcohol-related by the WHO. For a given total amount, daily drinking, heavy episodic drinking, and drinking outside of meals exacerbated the risks for four major diseases. Most observed associations were confirmed by genetic analyses, suggesting they are likely due to the alcohol itself rather than confounding factors. Limitations include potential residual confounding and the observational nature of the primary analysis.

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cohort

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epidemiology

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ORIGINAL PAPER

PMC10287564

Alcohol consumption and risks of more than 200 diseases in Chinese men

Nature Medicine

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ABSTRACT

Abstract Alcohol consumption accounts for ~3 million annual deaths worldwide, but uncertainty persists about its relationships with many diseases. We investigated the associations of alcohol consumption with 207 diseases in the 12-year China Kadoorie Biobank of >512,000 adults (41% men), including 168,050 genotyped for ALDH2 - rs671 and ADH1B - rs1229984 , with >1.1 million ICD-10 coded hospitalized events. At baseline, 33% of men drank alcohol regularly. Among men, alcohol intake was positively associated with 61 diseases, including 33 not defined by the World Health Organization as alcohol-related, such as cataract ( n = 2,028; hazard ratio 1.21; 95% confidence interval 1.09–1.33, per 280 g per week) and gout ( n = 402; 1.57, 1.33–1.86). Genotype-predicted mean alcohol intake was positively associated with established ( n = 28,564; 1.14, 1.09–1.20) and new alcohol-associated ( n = 16,138; 1.06, 1.01–1.12) diseases, and with specific diseases such as liver cirrhosis ( n = 499; 2.30, 1.58–3.35), stroke ( n = 12,176; 1.38, 1.27–1.49) and gout ( n = 338; 2.33, 1.49–3.62), but not ischemic heart disease ( n = 8,408; 1.04, 0.94–1.14). Among women, 2% drank alcohol resulting in low power to assess associations of self-reported alcohol intake with disease risks, but genetic findings in women suggested the excess male risks were not due to pleiotropic genotypic effects. Among Chinese men, alcohol consumption increased multiple disease risks, highlighting the need to strengthen preventive measures to reduce alcohol intake. Subject terms: Risk factors, Epidemiology, Genetics research

CITATION EXPORT

Pek Kei Im, Neil Wright, Ling Yang et al.. Alcohol consumption and risks of more than 200 diseases in Chinese men. Nature Medicine. (2023). https://doi.org/10.1038/s41591-023-02383-8

AUTHORS

20 · 29 CENTRES

Pek Kei Im, Neil Wright, Ling Yang, Ka Hung Chan, Yiping Chen, Yu Guo, Huaidong Du, Xiaoming Yang, Daniel Avery, Shaojie Wang, Canqing Yu, Jun Lv, Robert Clarke, Junshi Chen, Rory Collins, Robin G Walters, Richard Peto, Liming Li, Zhengming Chen, Iona Y Millwood

1Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK
2Medical Research Council Population Health Research Unit (MRC PHRU), Nuffield Department of Population Health, University of Oxford, Oxford, UK
3Oxford British Heart Foundation Centre of Research Excellence, University of Oxford, Oxford, UK
4Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, China
5NCD Prevention and Control Department, Qingdao CDC, Qingdao, China
6Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China
7Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing, China
8China National Center for Food Safety Risk Assessment, Beijing, China
9WHO Collaborating Center for Tobacco Cessation and Respiratory Diseases Prevention, China-Japan Friendship Hospital, Beijing, China
10Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China
11NCD Prevention and Control Department, Guangxi Provincial CDC, Nanning, China
12NCD Prevention and Control Department, Liuzhou CDC, Liubei, Liuzhou, China
13NCD Prevention and Control Department, Gansu Provincial CDC, Lanzhou, China
14NCD Prevention and Control Department, Maijixiang CDC, Maijixiang, Tianshui, China
15NCD Prevention and Control Department, Hainan Provincial CDC, Haikou, China
16NCD Prevention and Control Department, Meilan CDC, Meilan, Haikou, China
17NCD Prevention and Control Department, Heilongjiang CDC, Harbin, China
18NCD Prevention and Control Department, Nangang CDC, Harbin, China
19NCD Prevention and Control Department, Henan Provincial CDC, Zhengzhou, China
20NCD Prevention and Control Department, Huixian CDC, Huixian, China
21NCD Prevention and Control Department, Hunan Provincial CDC, Changsha, China
22NCD Prevention and Control Department, Liuyang CDC, Liuyang, China
23NCD Prevention and Control Department, Jiangsu Provincial CDC, Nanjing, China
24NCD Prevention and Control Department, Wuzhong CDC, Wuzhong, Suzhou, China
25NCD Prevention and Control Department, Licang CDC, Qingdao, China
26NCD Prevention and Control Department, Sichuan Provincial CDC, Chengdu, China
27NCD Prevention and Control Department, Pengzhou CDC, Pengzhou, Chengdu, China
28NCD Prevention and Control Department, Zhejiang Provincial CDC, Hangzhou, China
29NCD Prevention and Control Department, Tongxiang CDC, Tongxiang, China