Animals : an Open Access Journal from MDPI · 6 authors, 4 centres
This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.
This study used an in vitro porcine digestion model and a Caco-2/THP1 cell co-culture to evaluate three torula yeast formulations as alternative pig feed proteins. It found that yeast cultivated on wood and processed by spray-drying or drum-drying significantly improved epithelial barrier integrity and reduced pro-inflammatory cytokines in the cell model.
The study evaluated amino acid digestibility of three torula yeast ingredients produced using different carbon sources (wood or corn dextrose) and drying methods (drum- or spray-drying) in an in vitro porcine gastrointestinal digestion model. The intestinal digests were then tested for their protective effects on inflammation-induced epithelial damage in a Caco-2/THP1 co-culture model. Two wood-based products (drum-dried WDI and spray-dried WSI) significantly increased transepithelial electrical resistance (111–147%), recovering the epithelial barrier in a dose-dependent manner. WSI digests significantly reduced levels of pro-inflammatory cytokines IL8, IL6, and TNF. The authors conclude that wood-derived torula yeast ingredients can protect the intestinal barrier and reduce inflammation, suggesting their potential as high-quality protein feeds for pigs, though effects may vary based on carbon source and manufacturing process.
