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TL;DR
This editorial summarizes a Special Issue on amino acid metabolism, compiling original research and reviews across animal and human studies.
International Journal of Molecular Sciences · 2 authors, 2 centres
This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.
This editorial summarizes a Special Issue on amino acid metabolism, compiling original research and reviews across animal and human studies.
This editorial summarizes the Special Issue "Amino Acid Metabolism and Regulation in Health and Disease 2.0", which includes 10 original articles and 4 comprehensive reviews, aiming to highlight novel findings in amino acid metabolism beyond protein and nutrition roles. Methods: The studies compiled use various methods, including animal models (eels, mice, rats, pigs) and human clinical trials (e.g., 130 children with atopic diseases, 17 healthy volunteers), with techniques like GC-MS, dietary interventions, and biochemical analyses. Key Results: Key findings include methionine supplementation increasing lipid deposition in eels, high-methionine diets inducing anxiety-like behavior in mice, development of TCA as a biomarker in human urine, activation of the Arg/NOS pathway in children with atopic diseases, effects of nitrate supplementation on amino acid homeostasis in volunteers, valine/isoleucine supplementation improving growth in pigs, homoarginine administration affecting amino acid profiles in rat cardiomyopathy models, and essential amino acids with resistance exercise protecting against dexamethasone side effects in mice. Implications: The research underscores the importance of amino acids as signaling molecules in health and disease, with potential applications in nutrition, medicine, and agriculture, but further research is needed to elucidate mechanisms and clinical relevance.