Foods · 8 authors, 7 centres
This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.
This preclinical study investigated a novel herbal formula (MGF) in 3T3-L1 adipocyte cells and high-fat diet-fed rats. The formula, particularly MGF-3 and MGF-7, reduced intracellular lipid accumulation and GPDH activity in vitro and significantly attenuated body weight gain and adipose tissue mass in vivo. The study's primary limitation is its preclinical nature, requiring further research to determine mechanisms and human efficacy.
This study aimed to evaluate the anti-adipogenic and anti-obesity effects of an innovative herbal formula named Mei-Gin formula (MGF), composed of extracts from Prunus mume, Mesona procumbens Hemsl., and black garlic. Methods included in vitro analysis using 3T3-L1 preadipocytes and an in vivo model of high-fat diet (HFD)-induced obesity in Wistar rats. In vitro, MGF-1-7 treatments significantly reduced intracellular lipid accumulation and triglyceride content, with MGF-3 and MGF-7 showing the most potent effects (e.g., 250 μg/mL MGF-7 reduced triglycerides by 35.9%). This was associated with decreased glycerol-3-phosphate dehydrogenase (GPDH) activity. In the animal model, rats fed HFD for 8 weeks were supplemented with MGF-3, MGF-7, a Japanese Mei-Gin (JMG), or a positive control. Supplementation, especially with MGF-7 (both doses) and high-dose MGF-3, significantly attenuated HFD-induced increases in body weight, liver weight, and total body fat mass, including reductions in both visceral and subcutaneous adipose tissues. Key limitations include the preclinical design, lack of mechanistic pathway exploration, and the absence of human data. The findings suggest the MGF, particularly MGF-7, has potential as a dietary intervention for obesity management, but further research is needed.
