BMJ Open · 7 authors, 11 centres
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This observational case-control study evaluated how cardiovascular risk factors affect the viability of 1517 human corneal donors and their tissues. The central result was that COPD reduced donor and tissue viability, while smoking and alcohol consumption were associated with increased viability for certain measures.
This observational case-control study from a regional hospital in Northern Spain analyzed 1517 registered human corneas. The mean donor age was 61.3 years, and 81.5% had at least one cardiovascular risk factor. The study assessed the influence of these factors on donor viability, tissue viability, and implant suitability. Diabetes was associated with reduced tissue viability (OR=0.76). Conversely, alcohol consumption was associated with increased donor viability (OR=1.84), and an active smoking habit was associated with increased implant viability (OR=1.52). The findings suggest that assessing comorbidities can help guide decisions about donor and tissue quality in the absence of absolute exclusion criteria.
