Metabolites · 9 authors, 5 centres
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This animal study used a high-fat diet to induce hyperlipidemia in rats and employed mass spectrometry imaging to map liver metabolite changes over time. The central finding was that triglyceride (TG) levels were elevated in early stages but returned to control levels by the 14th week, and a specific TG species was identified as a key metabolite associated with the high-lipid state.
The study established a hyperlipidemia model in rats via a high-lipid diet. Pathological analysis showed hepatocyte swelling and steatosis in model rats. A key observation was that blood triglyceride (TG) levels were significantly higher in the early stage of the high-lipid model but decreased to levels similar to the control group by the 14th week. In situ mass spectrometry imaging (MSI) was used to analyze liver metabolite distribution, revealing significant differences between control and model rats at different stages. Nine functional metabolites showed differences, with TG(14:0/14:0/16:0) most significantly correlated with hyperlipidemia. The implications highlight the need to consider animal age when using TG as a biomarker and demonstrate MSI's utility for in situ metabolite visualization.
