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case-control·pediatrics, endocrinology, epidemiology, obstetrics and gynecology·PMC10032214

Analysis of Risk Factors and Screening Results of Neonatal Congenital Hypothyroidism in a Tertiary Care Center of Southern China

Journal of Multidisciplinary Healthcare · 4 authors, 2 centres

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TL;DR

Gestational thyroid disease, gestational diabetes mellitus, assisted reproduction, and small for gestational age were identified as significant influencing factors for CH and/or false-positive screening.

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This case-control study enrolled 255 neonates diagnosed with CH, 366 neonates with positive CH screening but normal thyroid function, and 246 healthy controls at a tertiary care center in southern China. Chi-square tests and multivariate logistic regression were used to analyze risk factors. Gestational thyroid disease (OR=8.452), gestational diabetes mellitus (OR=2.654), and assisted reproduction (OR=0.194) were significant influencing factors for neonatal CH. For false-positive screening results, SGA (OR=2.556), gestational thyroid disease (OR=7.801), gestational diabetes mellitus (OR=2.731), and assisted reproduction (OR=0.28) were significant factors. Assisted reproduction was a protective factor for both outcomes. Limitations include lack of analysis of genetic, environmental, and iodine-related risk factors, potential confounding from multiple concurrent pregnancy complications, and no further classification of CH type.

STUDY TYPE

case-control

SPECIALTY

pediatrics

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100% · A

ORIGINAL PAPER

PMC10032214

Analysis of Risk Factors and Screening Results of Neonatal Congenital Hypothyroidism in a Tertiary Care Center of Southern China

Journal of Multidisciplinary Healthcare

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ABSTRACT

Abstract Objective To explore the risk factors for neonatal congenital hypothyroidism (CH) and the influencing factors of false-positive results in CH screening. Methods In this study, 255 neonatal patients with CH who completed the screening and further diagnosis and 366 neonates with positive CH screening results and normal thyroid function were selected as the case group. 246 healthy neonates with normal thyroid function were selected as the control group. Gestational age, birth-weight, maternal age, small for gestational age (SGA), perinatal factors (gestational thyroid dysfunction, gestational diabetes mellitus, etc.) were used as influencing factors, using χ 2 tests were performed for comparison. The statistically significant variables were analyzed with Logistic multiple regression models, and the difference was considered statistically significant (P<0.05). Results There were statistical differences in the SGA, maternal gestational diabetes mellitus, thyroid disease, and the proportion using assisted reproduction technology among the case group, false-positive screening group, and control group ( χ 2 was 11.943, 6.857, 6.999, 9.732, respectively, P < 0.05). The results of multivariate logistic regression analysis showed that the gestational thyroid disease (OR = 8.452, 95% CI:1.051–67.982), gestational diabetes mellitus (OR = 2.654, 95% CI:1.051–6.706), and assisted reproduction (OR = 0.194, 95% CI:0.041–0.911) were the influencing factors for neonatal CH, and the difference was statistically significant ( P < 0.05). The SGA (OR = 2.556, 95% CI:1.027–6.361), gestational thyroid disease (OR = 7.801, 95% CI:1.03–59.057), gestational diabetes mellitus (OR = 2.731, 95% CI:1.18–6.322), and assisted reproduction (OR = 0.28, 95% CI:0.102–0.765) were the influencing factors of the false-positive screening results of neonatal CH. The difference was statistically significant ( P < 0.05). Conclusion Neonatal CH and positive screening results are influenced by assisted reproduction, gestational thyroid dysfunction, gestational diabetes mellitus, and SGA. Keywords: congenital hypothyroidism, false-positive, influencing factors, neonates

CITATION EXPORT

Xueqin Yan, Li Wang, Xiaolan Chen et al.. Analysis of Risk Factors and Screening Results of Neonatal Congenital Hypothyroidism in a Tertiary Care Center of Southern China. Journal of Multidisciplinary Healthcare. (2023). https://doi.org/10.2147/JMDH.S400804

AUTHORS

4 · 2 CENTRES

Xueqin Yan, Li Wang, Xiaolan Chen, Anru Wang

1Department of Child Health Care, Boai Hospital of Zhongshan Affiliated to Southern Medical University, Zhongshan, 528400, People’s Republic of China
2Department of Pediatrics, The Second of Affiliated Hospital of Nanjing Medical University, Nanjing, 210003, People’s Republic of China