SEARCHCROSS-SECTIONALepidemiology, cardiology

cross-sectional·epidemiology, cardiology, nephrology, internal medicine, public health·PMC10289511

Analysis of the association between serum antiaging humoral factor klotho and cardiovascular disease potential risk factor apolipoprotein B in general population

Medicine · 6 authors, 3 centres

AI SUMMARY

FIDELITY 100%

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

“

TL;DR

This inverse relationship persisted after adjusting for multiple potential confounders.

Full summary

129 CHARS

They found a significant negative association between ApoB concentration and serum Klotho in both unadjusted and adjusted models.

STUDY TYPE

cross-sectional

SPECIALTY

epidemiology

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10289511

Analysis of the association between serum antiaging humoral factor klotho and cardiovascular disease potential risk factor apolipoprotein B in general population

Medicine

READ THE FULL PAPER

ABSTRACT

Abstract Cardiovascular disease (CVD) is a prevalent health issue, and various risk factors contribute to its development, including blood lipids, blood pressure, diabetes, smoking, and alcohol consumption. Apolipoprotein B (ApoB) is related to CVD. ApoB is present on the surface of low-density lipoprotein (LDL), and its cellular recognition and LDL uptake are mainly achieved through recognition. It plays a crucial role in the diagnosis and treatment of CVD. This study aims to investigate the relationship between Klotho and ApoB in the general population of the United States as the correlation between serum Klotho and apoB is currently unknown. These findings could potentially guide the development of future treatments for CVD. This study utilized data from the National Health and Nutrition Examination Survey (NHANES) collected between 2007 and 2016. A linear regression model and smooth curve fitting were conducted to analyze the relationship between serum Klotho and apoB. The results indicate a negative correlation between serum Klotho concentration and apoB concentration (β = −71.7; 95% confidence interval [CI]: −120.8, −22.6; P = .005). After adjusting for confounding variables, the negative correlation between apoB concentration and serum Klotho concentration became more significant (β = −91.8; 95% CI: −151.3, −32.2; P = .004). When apoB concentration was converted from a continuous variable to a categorical variable (tertiles: T1 <0.8 g/L; T2: ≥0.8 g/L to <1.0 g/L; T3: ≥1.0 g/L), the serum klotho level of participants in the highest tertile (≥1.0 g/L) was −44.8 pg/mL (95% CI: −86.3, −3.2; P = .040) lower than that in the lowest tertile (<0.8 g/L). The smooth curve fitting diagram revealed differences in the relationship between serum Klotho concentration and apoB among individuals with different CVD risk factors. This study demonstrates a significant negative correlation between serum Klotho concentration and apoB concentration, even after controlling for confounding factors. The findings suggest that serum Klotho and apoB may be involved in the development of CVD, and targeting these factors could be a potential approach for CVD prevention and treatment. Keywords: ApoB, CVD, Klotho, NHANES

CITATION EXPORT

Zhiyi Chen, Tao Tao, Guixiao Huang et al.. Analysis of the association between serum antiaging humoral factor klotho and cardiovascular disease potential risk factor apolipoprotein B in general population. Medicine. (2023). https://doi.org/10.1097/MD.0000000000034056

AUTHORS

6 · 3 CENTRES

Zhiyi Chen, Tao Tao, Guixiao Huang, Xin Tong, Qinhe Li, Guanyu Su

a Department of Urology, The Affiliated Luohu Hospital of Shenzhen University, Shenzhen University School of Medicine, Shenzhen, China
b Shenzhen Following Precision Medical Research Institute, Luohu Hospital Group, Shenzhen, China
c Shantou University Medical College, Shantou, China.