Abstract The Animal Metabolite Database (AMDB, https://amdb.online ) is a freely accessible database with built-in statistical analysis tools, allowing one to browse and compare quantitative metabolomics data and raw NMR and MS data, as well as sample metadata, with a focus on the metabolite concentrations rather than on the raw data itself. AMDB also functions as a platform for the metabolomics community, providing convenient deposition and exchange of quantitative metabolomic data. To date, the majority of the data in AMDB relate to the metabolite content of the eye lens and blood of vertebrates, primarily wild species from Siberia, Russia and laboratory rodents. However, data on other tissues (muscle, heart, liver, brain, and more) are also present, and the list of species and tissues is constantly growing. Typically, every sample in AMDB contains concentrations of 60–90 of the most abundant metabolites, provided in nanomoles per gram of wet tissue weight (nmol/g). We believe that AMDB will become a widely used tool in the community, as typical metabolite baseline concentrations in tissues of animal models will aid in a wide variety of fundamental and applied scientific fields, including, but not limited to, animal modeling of human diseases, assessment of medical formulations, and evolutionary and environmental studies. Keywords: database, quantitative metabolomics, data reuse, data exchange, animal tissues, NMR spectroscopy, LC-MS
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Vadim V Yanshole, Arsenty D Melnikov, Lyudmila V Yanshole et al.. Animal Metabolite Database: Metabolite Concentrations in Animal Tissues and Convenient Comparison of Quantitative Metabolomic Data. Metabolites. (2023). https://doi.org/10.3390/metabo13101088 Vadim V Yanshole, Arsenty D Melnikov, Lyudmila V Yanshole, Ekaterina A Zelentsova, Olga A Snytnikova, Nataliya A Osik, Maxim V Fomenko, Ekaterina D Savina, Anastasia V Kalinina, Kirill A Sharshov, Nikita A Dubovitskiy, Mikhail S Kobtsev, Anatolii A Zaikovskii, Sofia S Mariasina, Yuri P Tsentalovich
1Laboratory of Proteomics and Metabolomics, International Tomography Center SB RAS, Institutskaya Str. 3a, Novosibirsk 630090, Russia; [email protected] (A.D.M.); [email protected] (L.V.Y.); [email protected] (E.A.Z.); [email protected] (O.A.S.); [email protected] (N.A.O.); [email protected] (M.V.F.); [email protected] (E.D.S.); [email protected] (A.V.K.); [email protected] (Y.P.T.) 2Department of Physics, Novosibirsk State University, Pirogova Str. 1, Novosibirsk 630090, Russia 3Laboratory of Molecular Epidemiology and Biodiversity of Viruses, Federal Research Center of Fundamental and Translational Medicine, Timakova Str. 2, Novosibirsk 630117, Russia; [email protected] (K.A.S.); [email protected] (N.A.D.) 4Department of Information Technologies, Novosibirsk State University, Pirogova Str. 1, Novosibirsk 630090, Russia; [email protected] 5Department of Mathematics and Computer Science, Saint Petersburg State University, 14th Line V. O. 29, Saint Petersburg 199178, Russia; [email protected] 6Department of Chemistry, Lomonosov Moscow State University, Moscow 119991, Russia; [email protected] 7Faculty of Fundamental Medicine, Lomonosov Moscow State University, Moscow 119991, Russia 8RUDN University, Miklukho-Maklaya Str. 6, Moscow 117198, Russia 