Anti-Diabetic Activity of a Novel Exopolysaccharide Produced by the Mangrove Endophytic Fungus Penicillium janthinellum N29

Marine Drugs · 5 authors, 3 centres

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TL;DR

This study isolated a novel exopolysaccharide (PJ1-1) from a fungus and tested its effects in a mouse model of type 2 diabetes. The compound significantly reduced blood glucose levels, improved insulin sensitivity, and alleviated dyslipidemia in the diabetic mice.

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The study characterized a novel galactomannan exopolysaccharide (PJ1-1) from the fungus Penicillium janthinellum N29. Its anti-diabetic effects were evaluated in vitro using an α-glucosidase inhibition assay and in vivo using a mouse model of type 2 diabetes mellitus induced by a high-fat diet and streptozotocin. Key results showed that PJ1-1 markedly reduced blood glucose levels, improved glucose tolerance, increased insulin sensitivity, and ameliorated insulin resistance in the mice. Furthermore, it significantly improved lipid profiles by decreasing serum total cholesterol, triglycerides, and LDL cholesterol, while increasing HDL cholesterol. The study concludes that PJ1-1 is a potential anti-diabetic agent, though it notes that further research on its mechanism is needed.

STUDY TYPE

other

SPECIALTY

preclinical research

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AI pipeline

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ORIGINAL PAPER

PMC10220899

Anti-Diabetic Activity of a Novel Exopolysaccharide Produced by the Mangrove Endophytic Fungus Penicillium janthinellum N29

Marine Drugs

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ABSTRACT

Marine microorganisms often produce exopolysaccharides with novel structures and diverse biological activities due to their specific marine environment. The novel active exopolysaccharides from marine microorganisms have become an important research area in new drug discovery, and show enormous development prospects. In the present study, a homogeneous exopolysaccharide from the fermented broth of the mangrove endophytic fungus Penicillium janthinellum N29, designated as PJ1-1, was obtained. The results of chemical and spectroscopic analyses showed that PJ1-1 was a novel galactomannan with a molecular weight of about 10.24 kDa. The backbone of PJ1-1 was composed of →2)-α- d -Man p -(1→, →4)-α- d -Man p -(1→, →3)-β- d -Gal f -(1→ and →2)-β- d -Gal f -(1→ units with partial glycosylation at C-3 of →2)-β- d -Gal f -(1→ unit. PJ1-1 had a strong hypoglycemic activity in vitro, evaluated using the assay of α-glucosidase inhibition. The anti-diabetic effect of PJ1-1 in vivo was further investigated using mice with type 2 diabetes mellitus induced by a high-fat diet and streptozotocin. The results indicated that PJ1-1 markedly reduced blood glucose level and improved glucose tolerance. Notably, PJ1-1 increased insulin sensitivity and ameliorated insulin resistance. Moreover, PJ1-1 significantly decreased the levels of serum total cholesterol, triglyceride and low-density lipoprotein cholesterol, enhanced the level of serum high-density lipoprotein cholesterol and alleviated dyslipidemia. These results revealed that PJ1-1 could be a potential source of anti-diabetic agent.

CITATION EXPORT

Zhuling Shao, Yingying Tian, Shan Liu et al.. Anti-Diabetic Activity of a Novel Exopolysaccharide Produced by the Mangrove Endophytic Fungus Penicillium janthinellum N29. Marine Drugs. (2023). https://doi.org/10.3390/md21050270

AUTHORS

5 · 3 CENTRES

Zhuling Shao, Yingying Tian, Shan Liu, Xiao Chu, Wenjun Mao

1Key Laboratory of Marine Drugs of Ministry of Education, Shandong Provincial Key Laboratory of Glycoscience and Glycotechnology, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
2Marine Biomedical Research Institute of Qingdao, Qingdao 266237, China
3Laboratory for Marine Drugs and Bioproducts, National Laboratory for Marine Science and Technology (Qingdao), Qingdao 266237, China

EDITOR / REVIEWER

Ralph Urbatzka