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RCT·nephrology, endocrinology, clinical nutrition, vitamins, internal medicine·PMC10040984

Anti-proteinuria effect of active vitamin D in patients with type 2 diabetic nephropathy

Journal of Family Medicine and Primary Care · 5 authors, 4 centres

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TL;DR

This randomized controlled trial evaluated 0.25 mg of active vitamin D (calcitriol) daily for 12 weeks in 40 patients with type 2 diabetic nephropathy. The study found that active vitamin D significantly reduced proteinuria compared to the control group.

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The primary outcome was proteinuria. Repeated measures analysis showed a significant reduction in proteinuria in the intervention group (P = 0.000). No significant changes were found in fasting blood sugar, calcium, phosphorus, creatinine, GFR, or blood pressure over time within the intervention group.

STUDY TYPE

RCT

SPECIALTY

nephrology

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100% · A

ORIGINAL PAPER

PMC10040984

Anti-proteinuria effect of active vitamin D in patients with type 2 diabetic nephropathy

Journal of Family Medicine and Primary Care

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ABSTRACT

A BSTRACT Introduction: Proteinuria is a common complication in patients with type 2 diabetic nephropathy (DN). The aim of this study was to evaluate the anti-proteinuria effect of active vitamin D in patients with type 2 DN. Methods: A double-blind randomized clinical trial study was conducted on 42 DN patients selected by convenience sampling method. After selecting patients based on inclusion criteria, they were randomly divided into control and intervention groups. Patients in the intervention group received 0.25 mg of active vitamin D per day for 12 weeks. The variables evaluated in the patients on the first day of the intervention included fasting blood sugar (FBS), calcium, phosphorus, creatinine, glomerular filtration rate (GFR), systolic and diastolic blood pressure, and proteinuria. These variables were also evaluated at the end of the first, second, and third month of intervention. Data were collected and analyzed in Statistical Package for Social Sciences software version 22. Results: Around 52.5% of the patients participating in this study were male and 47.5% were female. The mean age of the patients was 55.52 ± 6.58 years. The results of repeated measures analysis showed that active vitamin D significantly reduced proteinuria ( P = 0.000) in patients in the intervention group. The changes in FBS ( P = 0.235), calcium ( P = 0.393), phosphorus ( P = 0.694), creatinine ( P = 0.232), GFR ( P = 0.347), systolic blood pressure ( P = 0.615), and diastolic blood pressure ( P = 0.115) were not significant in patients in the intervention group. Conclusion: Prescription of active vitamin D can significantly reduce the incidence of proteinuria in patients with DN.

CITATION EXPORT

Asieh Aref, Mina Khodhal, Homeira Rashidi et al.. Anti-proteinuria effect of active vitamin D in patients with type 2 diabetic nephropathy. Journal of Family Medicine and Primary Care. (2022). https://doi.org/10.4103/jfmpc.jfmpc_627_22

AUTHORS

5 · 4 CENTRES

Asieh Aref, Mina Khodhal, Homeira Rashidi, Zahra Farhangiyan, Saeid Bitaraf

1 Department of Internal Medicine, School of Medicine, Chronic Renal Failure Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2 Department of Internal Medicine, Golestan Hospital, Chronic Renal Failure Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3 Diabetes Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4 Department of Biostatistics and Epidemiology, Clinical Research Sciences Institute, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran