Journal of Fungi · 11 authors, 5 centres
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Researchers isolated 107 endophytic fungi from the medicinal plant Arrabidaea chica and tested their extracts for antimicrobial and antioxidant activity. They found that extracts from the fungus Botryosphaeria mamane showed significant antimicrobial activity, and an extract from Colletotrichum sp. exhibited antioxidant activity comparable to the standard quercetin.
This preclinical study isolated 107 endophytic fungi from the aerial parts of the Amazonian medicinal plant Arrabidaea chica and screened their ethyl acetate extracts for biological activity. In vitro assays showed that 19% of extracts inhibited the growth of at least two human pathogens. The most promising antimicrobial extract was from Botryosphaeria mamane CF2-13, which exhibited activity against various bacteria and fungi, particularly Staphylococcus aureus and Candida parapsilosis with a Minimum Inhibitory Concentration (MIC) of 0.312 mg/mL. CG1-7 showed strong free radical scavenging in the DPPH assay with an EC50 of 11 µg/mL, comparable to the standard quercetin (8 µg/mL). The FRAP assay and TLC confirmed the presence of antioxidant phenolic compounds. The study concludes that endophytic fungi from A. chica are a promising source of bioactive metabolites. The findings support the bioprospecting of Amazonian endophytes for potential antimicrobial and antioxidant agents.
