Antioxidant and Anti-Inflammatory Activities of Stellera chamaejasme L. Roots and Aerial Parts Extracts
Life · 8 authors, 5 centres
AI SUMMARY
FIDELITY 100%
This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.
Ethanol and dichloromethane extracts from roots and aerial parts of Stellera chamaejasme L. were evaluated in vitro for antioxidant and anti-inflammatory activity. Roots extracts showed the strongest peroxyl radical scavenging (IC50 = 0.90 µg/mL for EtOH-R), and DCM-R most potently inhibited IL-6 production (≈91.5% reduction at 200 µg/mL) in LPS-stimulated macrophages without significant cytotoxicity.
Full summary
440 CHARS
TLC analysis revealed flavonoids only in EtOH-AP. The EtOH-R extract exhibited the highest antioxidant potency against peroxyl radicals (IC50 = 0.90 ± 0.07 µg/mL). All four extracts inhibited IL-6 production in a dose-dependent manner, with DCM-R being the most potent, reducing IL-6 by 91.5 ± 7.2% at 200 µg/mL with cell viability greater than 90%. GC-MS of DCM-R identified palmitic acid, 9-octadecenoic acid, 1-hexadecanol, and squalene.
