SEARCHSYSTEMATIC_REVIEWophthalmology, retina

systematic_review·ophthalmology, retina, surgery, hematology, systematic review·PMC10302284

Antiplatelets and Anticoagulants in Vitreoretinal Surgery: A Systematic Review

Life · 8 authors, 7 centres

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TL;DR

The included studies reported varying outcomes; for example, one study found warfarin was linked to a statistically significant increased risk of choroidal hemorrhage, while another concluded anticoagulation did not increase vitreous hemorrhage in diabetic patients.

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327 CHARS

STUDY TYPE

systematic_review

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ophthalmology

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100% · A

ORIGINAL PAPER

PMC10302284

Antiplatelets and Anticoagulants in Vitreoretinal Surgery: A Systematic Review

Life

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ABSTRACT

Abstract Background : Antiplatelets and anticoagulants have substantially influenced contemporary vitreoretinal surgical practices. The availability of new oral blood thinners has recently spurred a renewed interest in the clinical approach to vitreoretinal surgical conditions since it may be difficult for the surgeon to collect sufficient evidence-based data to decide whether to discontinue or continue such medications. Materials and Methods : We conducted a systematic review on the use of antiplatelets and/or anticoagulants in the perioperative setting in vitreoretinal surgery and their possible complications, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The level of evidence, according to the Oxford Centre for Evidence-Based Medicine (OCEM) 2011 guidelines, and the quality of evidence, according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system, were assessed for all included articles. Results : In total, 2310 articles were initially extracted, out of which 1839 articles were obtained after duplicates were removed and their abstracts were screened. A total of 27 articles were included in the full-text review. Finally, a remaining 22 articles fulfilled the inclusion criteria. Conclusions : Even though there is just a small number of studies with solid results, the advantage of using antiplatelets and/or anticoagulants in vitreoretinal surgery seems to outweigh the disadvantages, which are mainly related to postoperative hemorrhagic complications. Keywords: vitreoretinal surgery, surgical technique, antiplatelet, anticoagulant, eye surgery

CITATION EXPORT

Filippo Confalonieri, Vanessa Ferraro, Alessandra Di Maria et al.. Antiplatelets and Anticoagulants in Vitreoretinal Surgery: A Systematic Review. Life. (2023). https://doi.org/10.3390/life13061362

AUTHORS

8 · 7 CENTRES

Filippo Confalonieri, Vanessa Ferraro, Alessandra Di Maria, Alessandro Gaeta, Josè Luis Vallejo-Garcia, Paolo Vinciguerra, Xhevat Lumi, Goran Petrovski

1Department of Ophthalmology, IRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano, 20089 Milan, Italy; [email protected] (V.F.); [email protected] (A.D.M.); [email protected] (J.L.V.-G.); [email protected] (P.V.)
2Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20090 Milan, Italy
3Center for Eye Research and Innovative Diagnostics, Department of Ophthalmology, Institute for Clinical Medicine, University of Oslo, Kirkeveien 166, 0450 Oslo, Norway; [email protected]
4Department of Ophthalmology, Oslo University Hospital, Kirkeveien 166, 0450 Oslo, Norway
5Department of Internal Medicine and Medical Specialties (DIMI), Università di Genova, Viale Benedetto XV, 6, 16132 Genova, Italy; [email protected]
6Eye Hospital, University Medical Centre Ljubljana, Zaloška Cesta 2, 1000 Ljubljana, Slovenia
7Department of Ophthalmology, University of Split School of Medicine and University Hospital Centre, 21000 Split, Croatia