SEARCHCROSS-SECTIONALophthalmology, retina

cross-sectional·ophthalmology, retina, nutrition, epidemiology, clinical nutrition·PMC10238041

Are dietary intake parameters of vitamin A, carotene, retinol appropriate factors to evaluate the risk of diabetic retinopathy?

Medicine · 3 authors, 1 centre

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TL;DR

In unadjusted analyses, higher quartiles of intake for all three nutrients were associated with significantly lower odds ratios for any DR, PDR, and VTDR.

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In unadjusted analyses, higher quartiles of intake for all three nutrients were associated with significantly lower odds ratios for any DR, PDR, and VTDR. However, after adjusting for confounding factors including age, sex, hypertension, hemoglobin A1c levels, and diabetes duration, these associations became statistically insignificant. The study concludes that dietary intake parameters alone are insufficient to evaluate the risk of DR and suggests that serum nutrient levels may be more informative.

STUDY TYPE

cross-sectional

SPECIALTY

ophthalmology

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ORIGINAL PAPER

PMC10238041

Are dietary intake parameters of vitamin A, carotene, retinol appropriate factors to evaluate the risk of diabetic retinopathy?

Medicine

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ABSTRACT

Abstract The purpose of this study is to investigate whether dietary parameters of vitamin A, carotene, and retinol are sufficient for assessing the risk of diabetic retinopathy (DR). This was a population-based cross sectional study using systematic stratified, multilevel, nationwide, clustered sampling methods. From 2008 to 2012, 1948 subjects aged ≥ 40 years who participated in the Korean National Health and Nutrition Examination Survey were included. Participants underwent standardized interviews, dietary vitamin A estimation, carotene and retinol level evaluation, and eye examination. Daily dietary intake was evaluated using data in the form of a single 24-hour recall. The odds ratio (OR) of dietary vitamin A between extreme quartiles for DR was 0.72 (95% confidence interval [CI], 0.45–1.16, P for trend = .462) after adjusting for covariates such as age, sex, hypertension, hemoglobin A1c levels, and diabetes duration. The adjusted OR of dietary carotene between extreme quartiles for DR was 0.65 (95% CI, 0.39–1.09, P for trend = .220). The adjusted OR of dietary retinol between extreme quartiles for DR was 1.05 (95% CI, 0.62–1.80, P for trend = .279). There was no statistical significance in proliferative DR and Vision-threatening Dr Our study did not find evidence that the risk of DR is correlated with dietary vitamin A levels. Dietary intake parameters of vitamin A, carotene, and retinol might be insufficient to determine the association between the risk of Dr To demonstrate an association for the risk of DR, the use of serum information and not dietary information is needed. Keywords: carotene, diabetic retinopathy, Korea, retinol, vitamin A

CITATION EXPORT

Yu-Jin Choi, Jin-Woo Kwon, Donghyun Jee. Are dietary intake parameters of vitamin A, carotene, retinol appropriate factors to evaluate the risk of diabetic retinopathy?. Medicine. (2023). https://doi.org/10.1097/MD.0000000000033969

AUTHORS

3 · 1 CENTRES

Yu-Jin Choi, Jin-Woo Kwon, Donghyun Jee

a Department of Ophthalmology and Visual Science, St. Vincent’s Hospital, College of Medicine, Catholic University of Korea, Suwon, Republic of Korea.