SEARCHCOHORToncology, obstetrics and gynecology

cohort·oncology, obstetrics and gynecology, nutrition, clinical nutrition, hematology·PMC10047427

Assessment of Peripheral Platelet to Lymphocyte Ratio and Prognostic Nutritional Index in the Efficacy and Prognosis of Radiotherapy for Cervical Cancer

Current Oncology · 4 authors, 1 centre

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TL;DR

The central result showed that patients with high PNI or low PLR had significantly better 3-year overall survival (OS) and progression-free survival (PFS) than those with low PNI or high PLR.

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The central result showed that patients with high PNI or low PLR had significantly better 3-year overall survival (OS) and progression-free survival (PFS) than those with low PNI or high PLR. Multivariate Cox regression analysis identified PNI and PLR as independent factors influencing OS. Treatment efficacy was defined by WHO criteria. Limitations include the small sample size, retrospective single-center design, and the lack of consensus on optimal cut-off values.

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oncology

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ORIGINAL PAPER

PMC10047427

Assessment of Peripheral Platelet to Lymphocyte Ratio and Prognostic Nutritional Index in the Efficacy and Prognosis of Radiotherapy for Cervical Cancer

Current Oncology

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ABSTRACT

Abstract This study aimed to evaluate the correlation between the pre-treatment peripheral platelet-to-lymphocyte ratio (PLR) and the prognostic nutritional index (PNI) with the efficacy and prognosis of radiotherapy for cervical cancer. A total of 110 patients with cervical cancer who received radiotherapy at our hospital from November 2017 to November 2020 were retrospectively analysed. The cut-off values of PLR and PNI were obtained using the receive operating characteristic curve (ROC) and the Youden index. The patients were divided into high PLR and low PLR and high PNI and low PNI groups. We compared the clinical characteristics, 3-year overall survival (OS), and progression-free survival (PFS) between the high and low PLR groups, as well as the high and low PNI groups of patients. Cox regression was used to analyse the factors influencing OS and PFS. The median follow-up duration was 26 months. The optimal cut-off value for PLR was 186.88 and that for PNI was 47.35. The 3-year OS values were 81.00% and 97.10% for the high PLR (PLR > 186.88) and low PLR (PLR ≤ 186.88) groups, respectively, and the 3-year PFS values were 59.50% and 88.20% for the high PLR and low PLR groups, respectively, with statistically significant differences ( p < 0.05). The 3-year OS values were 97.50% and 74.20% for the high PNI (PNI > 47.35) and the low PNI (PNI ≤ 47.35) groups, respectively, and the 3-year PFS values were 87.30% and 51.60% for the high PNI and low PNI groups, respectively, with statistically significant differences ( p < 0.05). Multifactorial Cox regression analyses revealed that high PLR value (PLR > 187.88), low PNI value (PNI ≤ 47.35), histological type, and FIGO stage were independent risk factors for the OS of cervical cancer. Pretreatment PNI values and PLR values can be used as simple and feasible predictors of clinical efficacy and prognosis for patients treated with radiotherapy for cervical cancer. Keywords: cervical cancer, prognosis of radiotherapy, prognostic nutritional index, platelet to lymphocyte ratio

CITATION EXPORT

Zhongrong Gao, Mengli Zhao, Xiaojing Yang et al.. Assessment of Peripheral Platelet to Lymphocyte Ratio and Prognostic Nutritional Index in the Efficacy and Prognosis of Radiotherapy for Cervical Cancer. Current Oncology. (2023). https://doi.org/10.3390/curroncol30030216

AUTHORS

4 · 1 CENTRES

Zhongrong Gao, Mengli Zhao, Xiaojing Yang, Jie Fu

1Department of Radiotherapy, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China