The American journal of clinical nutrition · 9 authors, 4 centres
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This multicountry cross-sectional analysis of nationally representative surveys from 6 countries examined correlations between inflammation biomarkers (CRP, AGP) and serum 25(OH)D in preschool children and females of reproductive age. Correlations were weak and inconsistent, providing no rationale to adjust vitamin D deficiency prevalence estimates for inflammation.
Correlations between CRP and 25(OH)D ranged from −0.04 to 0.08 for PSC and from −0.11 to 0.14 for FRA; correlations between AGP and 25(OH)D ranged from 0.01 to 0.05 for PSC and from −0.05 to 0.01 for FRA. All correlations were weak, inconsistent in direction across countries, and most P values exceeded 0.05. Subgroup analyses by BMI status suggested body fat may modify these associations but yielded no consistent pattern. Limitations include variability in laboratory methods across surveys, lack of data on other inflammatory biomarkers, potential selection bias from biomarker availability constraints, and the cross-sectional design. The findings do not support adjusting 25(OH)D estimates for inflammation in population-based surveys of PSC or FRA.
