International Ophthalmology · 6 authors, 1 centre
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In a cross-sectional study of 31 patients with active systemic immune-related uveitis/scleritis compared to 31 age-matched controls, skin autofluorescence AGE levels did not differ significantly between groups (2.38 vs 2.58 AU, p=0.20), though multivariate analysis identified decreased SAF AGE level as independently associated with active ocular inflammation.
This prospective cross-sectional study at Siriraj Hospital enrolled 31 patients with systemic immune-related active non-infectious uveitis/scleritis and 31 age-matched healthy controls between October 2019 and March 2020. Patients with infectious ocular inflammation, diabetes, or cardiovascular disease were excluded. The most common associated disease was Vogt-Koyanagi-Harada (n=14). On univariate analysis, no variable was independently associated with uveitis/scleritis activity; however, multivariate analysis identified decreased SAF AGE level as significantly associated with active disease (OR: 0.01, 95% CI: 0.00004–0.81; p=0.04). The authors concluded that SAF AGE level is not a reliable biomarker for indicating uveitis/scleritis activity.
