Environmental Analysis, Health and Toxicology · 5 authors, 4 centres
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This cross-sectional study of 98 women found that higher exposure to certain environmental pollutants, specifically trans,trans-muconic acid and 2-hydroxynaphthalene, was associated with a significantly faster increase in the FSH/AMH ratio (a marker of ovarian function decline) with age compared to lower exposure groups.
This study investigated the effect of environmental pollutant exposure on the age-related decline of ovarian reserve markers in 98 women. Researchers measured urinary levels of 16 pollutants and serum AMH and FSH levels. Participants were grouped into high and low exposure for each pollutant based on the median level. The primary analysis compared the slopes of change in AMH and the FSH/AMH ratio with age between the groups. The central result was that the FSH/AMH ratio increased with age more rapidly in the high-exposure groups for several pollutants. Specifically, the rate of increase was 5.2 times higher for high exposure to trans,trans-muconic acid (a benzene metabolite) and 3.7 times higher for high exposure to 2-hydroxynaphthalene (a polycyclic aromatic hydrocarbon metabolite) compared to their respective low-exposure groups. Multivariate regression identified age and pollutant levels as significant factors influencing AMH and the FSH/AMH ratio.
