Association between gut microbiota and psychiatric disorders: a systematic review

Frontiers in Psychology · 6 authors, 3 centres

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TL;DR

This systematic review of 18 human studies found an association between various psychiatric disorders and differences in gut microbiota composition, including reduced fermentative taxa and increased pro-inflammatory taxa.

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This systematic review followed PRISMA guidelines and analyzed 18 original human studies (15 case-control, 3 randomized controlled trials) from PubMed and Scopus published over the last 11 years. The review notes a reduction in fermentative bacterial taxa and a decrease in short-chain fatty acid production, alongside an increase in pro-inflammatory taxa in individuals with psychiatric conditions.

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systematic_review

SPECIALTY

psychiatry

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AI pipeline

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ORIGINAL PAPER

PMC10435258

Association between gut microbiota and psychiatric disorders: a systematic review

Frontiers in Psychology

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ABSTRACT

Abstract Introduction In recent years, it has been described that the dysbiosis of the intestinal microbiota plays a transcendental role in several pathologies. In this sense, the importance of the gut microbiota in the gut-brain axis, with a bidirectional communication, has been demonstrated. Furthermore, the gut microbiota has been linked with mood disorders and neuropsychiatric disorders. Methods A systematic review of two databases – PubMed and Scopus – was carried out following PRISMA guidelines. We included original studies in humans with a control group published in the last 11 years, which were assessed by the Critical Appraisal Skills Program (CASP) to confirm their quality. Eighteen articles met all the selection criteria. Results A review of the articles revealed an association between psychiatric disorders and different bacterial phyla. The studies we have reviewed have demonstrated differences between subjects with psychiatric disorders and controls and highlight a clear relationship between depression, stress, autism spectrum disorder (ASD), psychotic episodes, eating disorders, anxiety and brain function and the gut microbiota composition. Conclusion A reduction of fermentative taxa has been observed in different psychiatric disorders, resulting in a decrease in the production of short-chain fatty acids (SCFAs) and an increase in pro-inflammatory taxa, both of which may be consequences of the exacerbation of these pathologies. Keywords: gut microbiota, psychiatric disorders, human, dysbiosis, gut-brain axis

CITATION EXPORT

Carmen Grau-Del Valle, Javier Fernández, Eva Solá et al.. Association between gut microbiota and psychiatric disorders: a systematic review. Frontiers in Psychology. (2023). https://doi.org/10.3389/fpsyg.2023.1215674

AUTHORS

6 · 3 CENTRES

Carmen Grau-Del Valle, Javier Fernández, Eva Solá, Inmaculada Montoya-Castilla, Carlos Morillas, Celia Bañuls

1Department of Endocrinology and Nutrition, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Valencia, Spain
2Department of Medicine, University of Valencia, Valencia, Spain
3Department of Personality, Assessment and Psychological Treatment, University of Valencia, Valencia, Spain