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TL;DR
Specifically, the highest quintile of strength had 82% lower odds of heart failure compared to the lowest quintile.
Scientific Reports · 7 authors, 3 centres
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Specifically, the highest quintile of strength had 82% lower odds of heart failure compared to the lowest quintile.
The primary analysis used a generalized additive model to assess the association between handgrip strength and heart failure, adjusting for numerous covariates including age, gender, race, socioeconomic factors, BMI, lifestyle factors, and comorbidities. The central result was a negative association between handgrip strength and heart failure (OR=0.97 per unit increase, 95% CI=0.96–0.99). Comparing the highest to the lowest quintile of handgrip strength was associated with 82% lower odds of heart failure (OR=0.18, 95% CI=0.08–0.43). Subgroup analyses indicated the results were stable across different demographic and clinical groups. The authors note the cross-sectional design limits the ability to infer causality, and the study population may not be generalizable to all adults. The findings suggest a potential link between muscle function and heart failure risk, warranting further prospective research.