SEARCHCROSS-SECTIONALinternal medicine, geriatrics

cross-sectional·internal medicine, geriatrics, nephrology, epidemiology, family medicine·PMC10124892

Association between oral frailty and cystatin C-related indices—A questionnaire (OFI-8) study in general internal medicine practice

PLOS ONE · 11 authors, 7 centres

AI SUMMARY

FIDELITY 100%

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

“

TL;DR

This cross-sectional study of 251 older outpatients found that cystatin C-related indices (Cr/CysC and eGFRcys/eGFRcre) were significantly lower in those at high risk for oral frailty, as defined by the OFI-8 questionnaire.

Full summary

846 CHARS

This cross-sectional study included 251 Japanese outpatients aged ≥65 years from general internal medicine clinics. Participants were screened for oral frailty risk using the OFI-8 questionnaire, divided into low-to-moderate (score ≤3) and high (score ≥4) risk groups. Key cystatin C-related indices, including the creatinine-to-cystatin C ratio (Cr/CysC) and the ratio of cystatin C-based to creatinine-based estimated glomerular filtration rate (eGFRcys/eGFRcre), were compared between groups. Results showed that Cr/CysC and eGFRcys/eGFRcre were significantly lower in the high-risk oral frailty group for both men and women. Additionally, grip strength was significantly lower in the high-risk group for both sexes. The study identifies an association between systemic markers related to muscle mass and kidney function and oral frailty risk.

STUDY TYPE

cross-sectional

SPECIALTY

internal medicine

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10124892

Association between oral frailty and cystatin C-related indices—A questionnaire (OFI-8) study in general internal medicine practice

PLOS ONE

READ THE FULL PAPER

ABSTRACT

Abstract Background Cystatin C-related indices such as the ratio of creatinine to cystatin C (Cr/CysC) and the ratio of estimated glomerular filtration rate by cystatin C (eGFRcys) to creatinine eGFRcre (eGFRcys/eGFRcre) levels have been shown to be associated with muscle mass and strength and can be markers of sarcopenia. Oral frailty is defined as an age-related gradual loss of oral functions, accompanied by a decline in cognitive and physical functions. It results in adverse health-related outcomes in older age, including mortality, physical frailty, functional disability, poor quality of life, and increased hospitalization and falls. Therefore, poor oral health among the elderly is an important health concern due to its association with the pathogenesis of systemic frailty, suggesting it to be a multidimensional geriatric syndrome. The Oral Frailty Index-8 (OFI-8) is a questionnaire that can be used for easy screening of oral frailty. This study aimed to investigate whether cystatin C- related indices are different between patients with low to moderate risk of oral frailty and those at high risk of oral frailty, using the OFI-8 in attending a general internal medicine outpatient clinic. Materials and methods This is a cross-sectional study that included 251 patients with a mean age of 77.7±6.6 years and a median age of 77 years (128 men: mean age, 77.1±7.3 years; median age, 77 years and 123 women: mean age, 78.4±5.7 years; median age, 78 years) attending general internal medicine outpatient clinics. OFI-8 scores were tabulated by gender to determine whether there were differences between patients at low to moderate risk of oral frailty (OFI-8 score ≤3 points) and those at high risk (OFI-8 score ≥4 points) in Cr/CysC, eGFRcys/eGFRcre levels, height, weight, grip strength, etc. were examined. Results The OFI-8 score was higher in women than in men, suggesting that oral frailty is more common in women. Cr/CysC, eGFRcys/eGFRcre and grip strength were significantly lower in both men and women in the high-risk group for oral frailty (OFI-8 score ≥ 4). Height, hemoglobin level, red blood cell count, and serum albumin levels were significantly lower in men with an OFI-8 score ≥4. Receiver operating characteristic curve (ROC) analysis also showed that Cr/CysC and eGFRcys/eGFRcre were significantly associated with an OFI-8 score≥4 in both men and women. Conclusion Cr/CysC and eGFRcys/eGFRcre were significantly lower in the high-risk group for oral frailty on the OFI-8in both men and women. A relationship exists among cystatin C-related indices, which can effectively screen systemic frailty. Similarly, the OFI-8 score can be used to effectively screen oral frailty. Thus, a collaboration that incorporates both systemic and oral frailty from medical and dental perspectives is required.

CITATION EXPORT

Hiroshi Kusunoki, Kazumi Ekawa, Nozomi Kato et al.. Association between oral frailty and cystatin C-related indices—A questionnaire (OFI-8) study in general internal medicine practice. PLOS ONE. (2023). https://doi.org/10.1371/journal.pone.0283803

AUTHORS

11 · 7 CENTRES

Hiroshi Kusunoki, Kazumi Ekawa, Nozomi Kato, Keita Yamasaki, Masaharu Motone, Ken Shinmura, Fumiki Yoshihara, Hideo Shimizu, Masaki Mogi, Masaki Mogi, Masaki Mogi

1Department of Internal Medicine, Osaka Dental University, Hirakata, Osaka, Japan
2Department of General Internal Medicine, Hyogo Medical University, Nishinomiya, Hyogo, Japan
3Department of Hypertension and Nephrology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan
4Department of Environmental and Preventive Medicine, Hyogo Medical University, Nishinomiya, Hyogo, Japan
5Department of Health and Sports Sciences Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
6Faculty of Health Sciences, Osaka Dental University, Hirakata, Osaka, Japan
7Ehime University Graduate School of Medicine, JAPAN